Title:
POLYMORPHIC FORM OF REDUCED β-NICOTINAMIDE MONONUCLEOTIDE DISODIUM SALT, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/160405
Kind Code:
A1
Abstract:
Provided is a compound NMNH disodium salt, and the present invention in particular relates to a polymorph of a reduced β-nicotinamide mononucleotide disodium salt, and a preparation method therefor and the use thereof as a pharmaceutical ingredient, a healthcare product ingredient, a cosmetic ingredient, or a food additive, and a preparation containing the salts, which falls within the field of medicines, healthcare products, cosmetics and food additives. Specifically, provided is a polymorph of NMNH disodium salt, wherein the crystal has excellent solubility performance, and the stability performance, flow performance, hygroscopicity resistance and purification effect thereof is superior to that of amorphous forms. The crystal form has a simple preparation process, which is easy to control and suitable for large-scale production.
Inventors:
GAO XING (CN)
YU JIANJUN (CN)
XU QINYUAN (CN)
LI YINSHAN (CN)
LIU JIALING (CN)
CHANG LIULEI (CN)
YU JIANJUN (CN)
XU QINYUAN (CN)
LI YINSHAN (CN)
LIU JIALING (CN)
CHANG LIULEI (CN)
Application Number:
PCT/CN2023/075226
Publication Date:
August 31, 2023
Filing Date:
February 09, 2023
Export Citation:
Assignee:
EFFEPHARM SHANGHAI CO LTD (CN)
International Classes:
A23L33/13; C07H19/048; A61K8/60; A61P1/16; A61P3/10; A61P9/00; A61P9/04; A61P13/12; A61P15/00; A61P17/14; A61P21/00; A61P25/00; A61P27/02; A61P27/06; A61P29/00; A61P39/02; A61Q5/02; A61Q19/00; A61Q19/08; C07H1/06
Foreign References:
| CN115368423A | 2022-11-22 | |||
| CN113490676A | 2021-10-08 | |||
| CN110845548A | 2020-02-28 | |||
| CN107613990A | 2018-01-19 |
Other References:
DATABASE Registry 30 May 1987 (1987-05-30), ANONYMOUS : "3-Pyridinecarboxamide, 1,4-dihydro-1-(5-O-p hosphono-β-Dribofuranosyl)-, diso dium salt (9CI) (CA I NDEX NAME) ", XP093087157, Database accession no. 108347-85-9
LIU YAN, LUO CHENGTING, LI TING, ZHANG WENHAO, ZONG ZHAOYUN, LIU XIAOHUI, DENG HAITENG: "Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD + and Suppresses Glycolysis, the TCA Cycle, and Cell Growth", JOURNAL OF PROTEOME RESEARCH, AMERICAN CHEMICAL SOCIETY, vol. 20, no. 5, 7 May 2021 (2021-05-07), pages 2596 - 2606, XP093087158, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.0c01037
LIU YAO, CONG YALONG, ZHANG CHUANXI, FANG BOHUAN, PAN YUE, LI QIANGZI, YOU CHUN, GAO BEI, ZHANG JOHN Z. H., ZHU TONG, ZHANG LUJIA: "Engineering the biomimetic cofactors of NMNH for cytochrome P450 BM3 based on binding conformation refinement", RSC ADVANCES, vol. 11, no. 20, 24 March 2021 (2021-03-24), pages 12036 - 12042, XP093087159, DOI: 10.1039/D1RA00352F
LIU YAN, LUO CHENGTING, LI TING, ZHANG WENHAO, ZONG ZHAOYUN, LIU XIAOHUI, DENG HAITENG: "Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD + and Suppresses Glycolysis, the TCA Cycle, and Cell Growth", JOURNAL OF PROTEOME RESEARCH, AMERICAN CHEMICAL SOCIETY, vol. 20, no. 5, 7 May 2021 (2021-05-07), pages 2596 - 2606, XP093087158, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.0c01037
LIU YAO, CONG YALONG, ZHANG CHUANXI, FANG BOHUAN, PAN YUE, LI QIANGZI, YOU CHUN, GAO BEI, ZHANG JOHN Z. H., ZHU TONG, ZHANG LUJIA: "Engineering the biomimetic cofactors of NMNH for cytochrome P450 BM3 based on binding conformation refinement", RSC ADVANCES, vol. 11, no. 20, 24 March 2021 (2021-03-24), pages 12036 - 12042, XP093087159, DOI: 10.1039/D1RA00352F
Attorney, Agent or Firm:
XU & PARTNERS , LLC. et al. (CN)
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