Title:
POLYNUCLEOTIDE AND MEDICINAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2021/132589
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a polynucleotide that has modified sites in a translation region but yet sustains the translation activity. This problem can be solved by a polynucleotide that contains a translation region from an imitation codon to a termination codon, wherein: the translation region comprises n codons; n is a positive integer of 2 or greater; the n codons each comprise the first, second and third nucleotides; and, in at least two codons among the n codons, the first nucleotide is a sugar-modified nucleotide.
More Like This:
| JP2024026140 | Antibody against LILRB2 |
| WO2000061736 | RECOMBINANT AND MUTANT MAREK'S DISEASE VIRUS |
| WO/2005/046570 | HUMAN STEM CELL MATERIALS AND METHODS |
Inventors:
ABE HIROSHI (JP)
IWAI HIROTO (JP)
HOMMA MASAKAZU (JP)
ASANO KANA (JP)
HARADA KENJI (JP)
YAMAMOTO JUNICHIRO (JP)
SHINOHARA FUMIKAZU (JP)
MOTOSAWA KEIICHI (JP)
KIMURA YASUAKI (JP)
NAKAMOTO KOSUKE (JP)
IWAI HIROTO (JP)
HOMMA MASAKAZU (JP)
ASANO KANA (JP)
HARADA KENJI (JP)
YAMAMOTO JUNICHIRO (JP)
SHINOHARA FUMIKAZU (JP)
MOTOSAWA KEIICHI (JP)
KIMURA YASUAKI (JP)
NAKAMOTO KOSUKE (JP)
Application Number:
PCT/JP2020/048799
Publication Date:
July 01, 2021
Filing Date:
December 25, 2020
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
KYOWA KIRIN CO LTD (JP)
KYOWA KIRIN CO LTD (JP)
International Classes:
A61K48/00; A61P43/00; C07H21/02; C12N15/10; C12N15/11
Domestic Patent References:
| WO2014093574A1 | 2014-06-19 | |||
| WO2017123669A1 | 2017-07-20 |
Other References:
HOERNES, THOMAS PHILIPP ET AL.: "Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code", NUCLEIC ACIDS RESEARCH, vol. 44, no. 2, 2016, pages 852 - 862, XP055838402
HOERNES, THOMAS PHILIPP ET AL.: "Eukaryotic Translation Elongation is Modulated by Single Natural Nucleotide Derivatives in the Coding Sequences of mRNAs", GENES, vol. 10, no. 84, 25 January 2019 (2019-01-25), pages 1 - 12, XP055838407
NAKAMOTO, MARGARET A. ET AL.: "mRNA pseudouridylation affects RNA metabolism in the parasite Toxoplasma gondii", RNA, vol. 23, 2017, pages 1834 - 1849, XP055838414
NATURE REVIEWS DRUG DISCOVERY, vol. 13, 2014, pages 759 - 780
NATURE BIOTECHNOLOGY, vol. 35, no. 3, 2017, pages 193 - 197
DRUG DISCOVERY TODAY, vol. 13, no. 19-20, 2008, pages 842 - 855
NATURE, vol. 547, no. 7662, 2017, pages 222 - 226
NUCLEIC ACIDS RESEARCH, vol. 44, no. 2, 2015, pages 852 - 862
GENES, vol. 10, no. 2, 2019, pages 84
LOCKED NUCLEIC ACID (LNA, TETRAHEDRON LETTERS, vol. 38, 1997, pages 8735
TETRAHEDRON, vol. 54, 1998, pages 3607
ETHYLENE BRIDGED NUCLEIC ACID (ENA, NUCLEIC ACIDS RESEARCH, vol. 32, 2004, pages e175
CONSTRAINED ETHYL (CET, THE JOURNAL OF ORGANIC CHEMISTRY, vol. 75, 2010, pages 1569
AMIDO-BRIDGED NUCLEIC ACID (AMNA, CHEM BIO CHEM, vol. 13, 2012, pages 2513
SPIROCYCLOPROPYLENE BRIDGED NUCLEIC ACID (SCPBNA, CHEM. COMMUN., vol. 51, 2015, pages 9737
FLUORO HEXITOL NUCLEIC ACID (FHNA: "35", NAT. BIOTECHNOL., vol. 35, 2017, pages 238
UNLOCKED NUCLEIC ACID (UNA, MOL. THER. NUCLEIC ACIDS, vol. 2, 2013, pages e103
PEPTIDE NUCLEIC ACID (PNA, ACC. CHEM. RES., vol. 32, 1999, pages 624
OXY-PEPTIDE NUCLEIC ACID (OPNA, J. AM. CHEM. SOC., vol. 123, 2001, pages 4653
PEPTIDE RIBONUCLEIC ACID (PRNA, J. AM. CHEM. SOC., vol. 122, 2000, pages 6900
"124", J. AM. CHEM. SOC., 2002, pages 4962
NUCLEIC ACIDS RESEARCH, vol. 42, 2014, pages 13546
SCIENCE, vol. 361, 2018, pages 1234
NUCLEIC ACIDS RESEARCH, vol. 35, 2007, pages 3287
TETRAHEDRON, vol. 48, no. 12, 1992, pages 2223 - 2311
"Current Protocols in Nucleic Acids Chemistry", 2000, JOHN WILEY SONS
"Protocols for Oligonucleotides and Analogs", 1993, HUMAN PRESS
"Chemistry and Biology of Artificial Nucleic Acids", 2012, WILEY-VCH
"Genome Chemistry Jinko Kakusan wo Katsuyo suru Kagakuteki Approach (Scientific approach for utilizing artificial nucleic acids", 2003, KODANSHA LTD.
RNA, METHODS IN MOLECULAR BIOLOGY (METHODS AND PROTOCOLS, vol. 703, 2011
TOP. CURR. CHEM, 2017, pages 375 - 16
BEILSTEIN, J. ORG. CHEM., vol. 13, 2017, pages 2819 - 2832
MOLECULAR CELL, vol. 16, 22 October 2004 (2004-10-22), pages 211 - 221
J. AM. CHEM. SOC., vol. 121, 1999, pages 5661 - 5665
CARDIAC GENE THERAPY: METHODS IN MOLECULAR BIOLOGY (METHODS AND PROTOCOLS, vol. 1521, 2016
JOURNAL OF MOLECULAR BIOLOGY, vol. 249, 1995, pages 398 - 408
ORGANOMETALLICS, vol. 29, 2010, pages 2176 - 2179
HOERNES, THOMAS PHILIPP ET AL.: "Eukaryotic Translation Elongation is Modulated by Single Natural Nucleotide Derivatives in the Coding Sequences of mRNAs", GENES, vol. 10, no. 84, 25 January 2019 (2019-01-25), pages 1 - 12, XP055838407
NAKAMOTO, MARGARET A. ET AL.: "mRNA pseudouridylation affects RNA metabolism in the parasite Toxoplasma gondii", RNA, vol. 23, 2017, pages 1834 - 1849, XP055838414
NATURE REVIEWS DRUG DISCOVERY, vol. 13, 2014, pages 759 - 780
NATURE BIOTECHNOLOGY, vol. 35, no. 3, 2017, pages 193 - 197
DRUG DISCOVERY TODAY, vol. 13, no. 19-20, 2008, pages 842 - 855
NATURE, vol. 547, no. 7662, 2017, pages 222 - 226
NUCLEIC ACIDS RESEARCH, vol. 44, no. 2, 2015, pages 852 - 862
GENES, vol. 10, no. 2, 2019, pages 84
LOCKED NUCLEIC ACID (LNA, TETRAHEDRON LETTERS, vol. 38, 1997, pages 8735
TETRAHEDRON, vol. 54, 1998, pages 3607
ETHYLENE BRIDGED NUCLEIC ACID (ENA, NUCLEIC ACIDS RESEARCH, vol. 32, 2004, pages e175
CONSTRAINED ETHYL (CET, THE JOURNAL OF ORGANIC CHEMISTRY, vol. 75, 2010, pages 1569
AMIDO-BRIDGED NUCLEIC ACID (AMNA, CHEM BIO CHEM, vol. 13, 2012, pages 2513
SPIROCYCLOPROPYLENE BRIDGED NUCLEIC ACID (SCPBNA, CHEM. COMMUN., vol. 51, 2015, pages 9737
FLUORO HEXITOL NUCLEIC ACID (FHNA: "35", NAT. BIOTECHNOL., vol. 35, 2017, pages 238
UNLOCKED NUCLEIC ACID (UNA, MOL. THER. NUCLEIC ACIDS, vol. 2, 2013, pages e103
PEPTIDE NUCLEIC ACID (PNA, ACC. CHEM. RES., vol. 32, 1999, pages 624
OXY-PEPTIDE NUCLEIC ACID (OPNA, J. AM. CHEM. SOC., vol. 123, 2001, pages 4653
PEPTIDE RIBONUCLEIC ACID (PRNA, J. AM. CHEM. SOC., vol. 122, 2000, pages 6900
"124", J. AM. CHEM. SOC., 2002, pages 4962
NUCLEIC ACIDS RESEARCH, vol. 42, 2014, pages 13546
SCIENCE, vol. 361, 2018, pages 1234
NUCLEIC ACIDS RESEARCH, vol. 35, 2007, pages 3287
TETRAHEDRON, vol. 48, no. 12, 1992, pages 2223 - 2311
"Current Protocols in Nucleic Acids Chemistry", 2000, JOHN WILEY SONS
"Protocols for Oligonucleotides and Analogs", 1993, HUMAN PRESS
"Chemistry and Biology of Artificial Nucleic Acids", 2012, WILEY-VCH
"Genome Chemistry Jinko Kakusan wo Katsuyo suru Kagakuteki Approach (Scientific approach for utilizing artificial nucleic acids", 2003, KODANSHA LTD.
RNA, METHODS IN MOLECULAR BIOLOGY (METHODS AND PROTOCOLS, vol. 703, 2011
TOP. CURR. CHEM, 2017, pages 375 - 16
BEILSTEIN, J. ORG. CHEM., vol. 13, 2017, pages 2819 - 2832
MOLECULAR CELL, vol. 16, 22 October 2004 (2004-10-22), pages 211 - 221
J. AM. CHEM. SOC., vol. 121, 1999, pages 5661 - 5665
CARDIAC GENE THERAPY: METHODS IN MOLECULAR BIOLOGY (METHODS AND PROTOCOLS, vol. 1521, 2016
JOURNAL OF MOLECULAR BIOLOGY, vol. 249, 1995, pages 398 - 408
ORGANOMETALLICS, vol. 29, 2010, pages 2176 - 2179
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
Download PDF:
Previous Patent: SCANNING OPTICAL FUNDUS IMAGING DEVICE
Next Patent: POLYCARBONATE-POLYORGANOSILOXANE COPOLYMER
Next Patent: POLYCARBONATE-POLYORGANOSILOXANE COPOLYMER