Title:
POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES ASSOCIATED WITH CNS DEPRESSANT SENSITIVITY AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO1999038975
Kind Code:
A3
Abstract:
The invention provides polynucleotide and polypeptide sequences associated with CNS depressant sensitivity, and methods for identifying and classifying candidate CNS depressants as well as methods to identify agents which may modulate CNS depressant action. The invention also provides mouse mGluR5 polynucleotide and polypeptide sequences.
Inventors:
JOHNSON THOMAS E (US)
SIKELA JAMES M (US)
SIMPSON VICTORIA J (US)
RIKKE BRAD A (US)
SIKELA JAMES M (US)
SIMPSON VICTORIA J (US)
RIKKE BRAD A (US)
Application Number:
PCT/US1999/002033
Publication Date:
September 23, 1999
Filing Date:
January 29, 1999
Export Citation:
Assignee:
UNIV TECHNOLOGY CORP (US)
JOHNSON THOMAS E (US)
SIKELA JAMES M (US)
SIMPSON VICTORIA J (US)
RIKKE BRAD A (US)
JOHNSON THOMAS E (US)
SIKELA JAMES M (US)
SIMPSON VICTORIA J (US)
RIKKE BRAD A (US)
International Classes:
C07K14/705; C12N15/12; (IPC1-7): C12N15/12; C07K14/705; C07K16/28; G01N33/68
Domestic Patent References:
| WO1994029449A1 | 1994-12-22 |
Other References:
SOMMER, B. ET AL.: "RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.", CELL, vol. 67, 4 October 1991 (1991-10-04), pages 11 - 9, XP002108292
MINAKAMI, R. ET AL.: "The expression of two splice variants of metabotropic glutamate receptor subtype 5 in the rat brain and neural cells during development.", JOURNAL OF NEUROCHEMISTRY, vol. 65, no. 4, October 1995 (1995-10-01), pages 1536 - 42, XP002108290
DORRI, F. ET AL.: "Down-regulation of mGluR5 by antisense deoxynucleotides alters pharmacological responses to application of ACPD in the rat hippocampus.", EXPERIMENTAL NEUROLOGY, vol. 147, no. 1, September 1997 (1997-09-01), pages 48 - 54, XP002108293
MINAMI, K. ET AL.: "Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.", MOLECULAR PHARMACOLOGY, vol. 53, no. 1, 1 January 1998 (1998-01-01), pages 148 - 156, XP002108294
SIMPSON, V.J. ET AL.: "Mapping a major QTL for propofol neurosensitivity in F2 mice from an LS by SS cross.", ANESTHESIOLOGY, vol. 65, no. 3a, September 1996 (1996-09-01), pages a627, XP002108295
SCHEDL A ET AL: "A YEAST ARTIFICIAL CHROMOSOME COVERING THE TYROSINASE GENE CONFERS COPY NUMBER-DEPENDENT EXPRESSION IN TRANSGENIC MICE", NATURE, vol. 362, no. 6417, 18 March 1993 (1993-03-18), pages 258 - 261, XP000563891
PROCTER, M. ET AL.: "Possible role of GluR5 glutamate receptors in spinal nociceptive processing in the anaesthetized rat.", JOURNAL OF PHYSIOLOGY, vol. 504P, November 1997 (1997-11-01), pages 101P - 102P, XP002108296
ABE T ET AL: "MOLECULAR CHARACTERIZATION OF A NOVEL METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 COUPLED TO INOSITOL PHOSPHATE/CA2+ SIGNAL TRANSDUCTION", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 19, 5 July 1992 (1992-07-05), pages 13361 - 13368, XP000605387
SIMPSON, V.J. ET AL.: "Ketamine exerts differential hypnotic effects in long sleep and short sleep mice.", ANESTHESIOLOGY, vol. 89, no. 3a, September 1998 (1998-09-01), pages A128, XP002108299
MINAKAMI, R. ET AL.: "The expression of two splice variants of metabotropic glutamate receptor subtype 5 in the rat brain and neural cells during development.", JOURNAL OF NEUROCHEMISTRY, vol. 65, no. 4, October 1995 (1995-10-01), pages 1536 - 42, XP002108290
DORRI, F. ET AL.: "Down-regulation of mGluR5 by antisense deoxynucleotides alters pharmacological responses to application of ACPD in the rat hippocampus.", EXPERIMENTAL NEUROLOGY, vol. 147, no. 1, September 1997 (1997-09-01), pages 48 - 54, XP002108293
MINAMI, K. ET AL.: "Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.", MOLECULAR PHARMACOLOGY, vol. 53, no. 1, 1 January 1998 (1998-01-01), pages 148 - 156, XP002108294
SIMPSON, V.J. ET AL.: "Mapping a major QTL for propofol neurosensitivity in F2 mice from an LS by SS cross.", ANESTHESIOLOGY, vol. 65, no. 3a, September 1996 (1996-09-01), pages a627, XP002108295
SCHEDL A ET AL: "A YEAST ARTIFICIAL CHROMOSOME COVERING THE TYROSINASE GENE CONFERS COPY NUMBER-DEPENDENT EXPRESSION IN TRANSGENIC MICE", NATURE, vol. 362, no. 6417, 18 March 1993 (1993-03-18), pages 258 - 261, XP000563891
PROCTER, M. ET AL.: "Possible role of GluR5 glutamate receptors in spinal nociceptive processing in the anaesthetized rat.", JOURNAL OF PHYSIOLOGY, vol. 504P, November 1997 (1997-11-01), pages 101P - 102P, XP002108296
ABE T ET AL: "MOLECULAR CHARACTERIZATION OF A NOVEL METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 COUPLED TO INOSITOL PHOSPHATE/CA2+ SIGNAL TRANSDUCTION", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 19, 5 July 1992 (1992-07-05), pages 13361 - 13368, XP000605387
SIMPSON, V.J. ET AL.: "Ketamine exerts differential hypnotic effects in long sleep and short sleep mice.", ANESTHESIOLOGY, vol. 89, no. 3a, September 1998 (1998-09-01), pages A128, XP002108299
Download PDF:
Previous Patent: COMPOUNDS FOR THERAPY AND DIAGNOSIS OF LUNG CANCER AND METHODS FOR THEIR USE
Next Patent: HUMAN GROWTH FACTOR HOMOLOGS
Next Patent: HUMAN GROWTH FACTOR HOMOLOGS