Title:
POLYNUCLEOTIDES FOR USE IN RECOMBINANT ADENO-ASSOCIATED VIRUS VIRION PRODUCTION
Document Type and Number:
WIPO Patent Application WO2001083797
Kind Code:
A3
Abstract:
Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producing rAAV virions are also provided. The methods can be practiced to produce commercially significant levels of rAAV particles without also generating significant levels of infectious helper virus or other contaminating by-products.
Inventors:
COLOSI PETER (US)
Application Number:
PCT/US2001/040561
Publication Date:
March 13, 2003
Filing Date:
April 20, 2001
Export Citation:
Assignee:
AVIGEN INC (US)
COLOSI PETER (US)
COLOSI PETER (US)
International Classes:
C07K14/05; C07K14/075; C12N5/10; C12N7/01; C12N15/861; C12N15/864; (IPC1-7): C12N15/864; C12N5/10; C12N7/01; A61K48/00
Domestic Patent References:
| WO1997009441A2 | 1997-03-13 | |||
| WO2000022152A1 | 2000-04-20 |
Other References:
MATSUSHITA T. ET AL.: "Adeno-associated virus vectors can be efficiently produced without helper virus", GENE THERAPY, vol. 5, no. 7, July 1998 (1998-07-01), pages 938 - 945, XP002098259, ISSN: 0969-7128
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