Title:
POLYPEPTIDE, DERIVATIVES THEREOF, AND APPLICATION THEREOF IN PREPARATION OF DRUGS HAVING RESISTANCE TO PULMONARY FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2017/144016
Kind Code:
A1
Abstract:
Provided are a polypeptide specifically binding to TRB3 and application thereof in preparation of drugs for treating and/preventing pulmonary fibrosis. The amino acid sequence of the polypeptide is represented by SEQ ID No.12 in a sequence list, or two or more amino acids in the amino acid sequence as represented by SEQ ID No.12 in the sequence list are replaced with unnatural amino acids having side chains that can be linked to each other. The polypeptide and derivatives thereof can specifically bind to TRB3, thereby blocking the interaction between TRB3 and MDM2 proteins.
Inventors:
HU ZHUOWEI (CN)
LV XIAOXI (CN)
LIU SHANSHAN (CN)
LV XIAOXI (CN)
LIU SHANSHAN (CN)
Application Number:
PCT/CN2017/074792
Publication Date:
August 31, 2017
Filing Date:
February 24, 2017
Export Citation:
Assignee:
HU ZHUOWEI (CN)
International Classes:
C07K7/08; A61K38/10; A61P11/00; C07K1/113
Domestic Patent References:
| WO2011160016A2 | 2011-12-22 |
Foreign References:
| US20130217634A1 | 2013-08-22 | |||
| CN104740604A | 2015-07-01 |
Other References:
DATABASE Protein [O] 11 December 2014 (2014-12-11), "PREDICTED: E3 ubiquitin-protein ligase Mdm2 [Loxodonta africana]", XP055412042, Database accession no. XP_003405637.1
LIU, SHANSHAN: "ZU3DUAN4 TRB3/MDM2 XIANG1 HU 4ZU04YONG4 CU 4JIN4 SLUG JIANG4JIE3ZHI4LIA02 FEI4XIAN1WEI1HUA4", CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 15 January 2017 (2017-01-15), XP9514037, ISSN: 1674-022X
MUYING YING ET AL.: "Comprehensively Surveying Structure and Function of RING Domains from Drosophila melanogaster", PLOS ONE, vol. 6, 2 September 2011 (2011-09-02), pages e23863, XP055412046, ISSN: 1932-6203, [retrieved on 20110902]
See also references of EP 3421484A4
LIU, SHANSHAN: "ZU3DUAN4 TRB3/MDM2 XIANG1 HU 4ZU04YONG4 CU 4JIN4 SLUG JIANG4JIE3ZHI4LIA02 FEI4XIAN1WEI1HUA4", CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 15 January 2017 (2017-01-15), XP9514037, ISSN: 1674-022X
MUYING YING ET AL.: "Comprehensively Surveying Structure and Function of RING Domains from Drosophila melanogaster", PLOS ONE, vol. 6, 2 September 2011 (2011-09-02), pages e23863, XP055412046, ISSN: 1932-6203, [retrieved on 20110902]
See also references of EP 3421484A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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