Title:
POLYPEPTIDE DERIVED FROM DRY-CURED HAM AND CAPABLE OF ALLEVATING ALCOHOLIC LIVER DAMAGE, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/020290
Kind Code:
A1
Abstract:
A polypeptide derived from dry-cured ham and capable of alleviating alcoholic liver damage, and a preparation method therefor, wherein the amino acid sequence is Lys-Arg-Gln-Lys-Tyr-Asp. The active peptide has the functions of improving intestinal flora, reducing lipid accumulation in the liver and alleviating hepatic pressure at the same time; has the characteristics of a simple structure, being safe, having high activity, etc.; plays a role in nutrition and health care; is expected to provide effective components for developing new non-toxic food products without side effects for alleviating alcoholic liver damage; and has broad application prospects.
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Inventors:
XU BAOCAI (CN)
XU FEIRAN (CN)
NIE WEN (CN)
ZHOU HUI (CN)
YANG XIAOXIAO (CN)
LI PING (CN)
DONG XINRAN (CN)
XU FEIRAN (CN)
NIE WEN (CN)
ZHOU HUI (CN)
YANG XIAOXIAO (CN)
LI PING (CN)
DONG XINRAN (CN)
Application Number:
PCT/CN2022/110215
Publication Date:
February 23, 2023
Filing Date:
August 04, 2022
Export Citation:
Assignee:
UNIV HEFEI TECHNOLOGY (CN)
International Classes:
C07K7/06; A23L33/18; A61K38/08; A61P1/16; C07K1/16; C07K1/22; C07K1/34; G01N30/02; G01N30/72; G01N30/86
Domestic Patent References:
| WO2017018791A1 | 2017-02-02 | |||
| WO2018001273A1 | 2018-01-04 |
Foreign References:
| CN114304354A | 2022-04-12 | |||
| CN113480608A | 2021-10-08 | |||
| CN112979748A | 2021-06-18 |
Other References:
ZUO QING-XIANG, ZHANG WAN-GANG, XING LU-JUAN, ZHENG JIN-XIAO, ZHOU GUANG-HONG: "Stability of Angiotensin I-converting Enzyme Inhibitory Activity of Peptides Extracted from Dry-cured Jinhua Ham", JOURNAL OF FOOD AND NUTRITION RESEARCH, vol. 5, no. 5, 1 January 2017 (2017-01-01), pages 301 - 308, XP093035969, ISSN: 2333-1119, DOI: 10.12691/jfnr-5-5-3
ZANGIABADI MILAD, ZHAO YAN: "Molecularly Imprinted Polymeric Receptors with Interfacial Hydrogen Bonds for Peptide Recognition in Water", ACS APPLIED POLYMER MATERIALS, vol. 2, no. 8, 14 August 2020 (2020-08-14), pages 3171 - 3180, XP093035970, ISSN: 2637-6105, DOI: 10.1021/acsapm.0c00354
NIE WEN, DU YE-YE, XU FEI-RAN, ZHOU KAI, WANG ZHAO-MING, AL-DALALI SAM, WANG YING, LI XIAO-MIN, MA YUN-HAO, XIE YONG, ZHOU HUI, XU: "Oligopeptides from Jinhua ham prevent alcohol-induced liver damage by regulating intestinal homeostasis and oxidative stress in mice", FOOD & FUNCTION, vol. 12, no. 20, 17 August 2021 (2021-08-17), GB , pages 10053 - 10070, XP093035971, ISSN: 2042-6496, DOI: 10.1039/D1FO01693H
QI NAN, LIU CHEN, YANG HAORAN, SHI WANRONG, WANG SHENYI, ZHOU YAN, WEI CAI, GU FANG, QIN YIDE: "Therapeutic hexapeptide (PGPIPN) prevents and cures alcoholic fatty liver disease by affecting the expressions of genes related with lipid metabolism and oxidative stress", ONCOTARGET, vol. 8, no. 50, 20 October 2017 (2017-10-20), pages 88079 - 88093, XP093035972, DOI: 10.18632/oncotarget.21404
YUHONG WU;XINGCHANG PAN;SHIXIU ZHANG;WENXIAN WANG;MUYI CAI;YANRONG LI;FAN YANG;HONGWEI GUO: "Protective effect of corn peptides against alcoholic liver injury in men with chronic alcohol consumption: a randomized double-blind placebo-controlled study", LIPIDS IN HEALTH AND DISEASE, vol. 13, no. 1, 13 December 2014 (2014-12-13), GB , pages 192, XP021206950, ISSN: 1476-511X, DOI: 10.1186/1476-511X-13-192
ZANGIABADI MILAD, ZHAO YAN: "Molecularly Imprinted Polymeric Receptors with Interfacial Hydrogen Bonds for Peptide Recognition in Water", ACS APPLIED POLYMER MATERIALS, vol. 2, no. 8, 14 August 2020 (2020-08-14), pages 3171 - 3180, XP093035970, ISSN: 2637-6105, DOI: 10.1021/acsapm.0c00354
NIE WEN, DU YE-YE, XU FEI-RAN, ZHOU KAI, WANG ZHAO-MING, AL-DALALI SAM, WANG YING, LI XIAO-MIN, MA YUN-HAO, XIE YONG, ZHOU HUI, XU: "Oligopeptides from Jinhua ham prevent alcohol-induced liver damage by regulating intestinal homeostasis and oxidative stress in mice", FOOD & FUNCTION, vol. 12, no. 20, 17 August 2021 (2021-08-17), GB , pages 10053 - 10070, XP093035971, ISSN: 2042-6496, DOI: 10.1039/D1FO01693H
QI NAN, LIU CHEN, YANG HAORAN, SHI WANRONG, WANG SHENYI, ZHOU YAN, WEI CAI, GU FANG, QIN YIDE: "Therapeutic hexapeptide (PGPIPN) prevents and cures alcoholic fatty liver disease by affecting the expressions of genes related with lipid metabolism and oxidative stress", ONCOTARGET, vol. 8, no. 50, 20 October 2017 (2017-10-20), pages 88079 - 88093, XP093035972, DOI: 10.18632/oncotarget.21404
YUHONG WU;XINGCHANG PAN;SHIXIU ZHANG;WENXIAN WANG;MUYI CAI;YANRONG LI;FAN YANG;HONGWEI GUO: "Protective effect of corn peptides against alcoholic liver injury in men with chronic alcohol consumption: a randomized double-blind placebo-controlled study", LIPIDS IN HEALTH AND DISEASE, vol. 13, no. 1, 13 December 2014 (2014-12-13), GB , pages 192, XP021206950, ISSN: 1476-511X, DOI: 10.1186/1476-511X-13-192
Attorney, Agent or Firm:
SUZHOU XIANGYUAN PATENT AGENCY(GENERAL PARTNERSHIP) (CN)
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