Title:
POLYPEPTIDE AND DESIGN METHOD THEREFOR, AND APPLICATION THEREOF IN PREPARING DRUG FOR INHIBITING FUSOBACTERIUM NUCLEATUM PRODUCT OR PREVENTING COLORECTAL CANCER
Document Type and Number:
WIPO Patent Application WO/2023/241675
Kind Code:
A1
Abstract:
Disclosed are a polypeptide and a design method therefor, and an application thereof in preparing a drug for inhibiting a Fusobacterium nucleatum (F. Nucleatum) product or preventing colorectal cancer, relating to the field of polypeptides. The polypeptide comprises hydrophobic amino acids and charged amino acids, and the amino acid sequence of the polypeptide is distributed as a symmetrical structure. The polypeptide of the present application takes natural amino acid residues as basic components, has inherent biocompatibility and biodegradability, can specifically kill F. nucleatum, has relatively low antibacterial activity on other bacteria, and does not have the side effect of antibiotics killing normal flora. Therefore, the polypeptide can be used for long-term limiting of in vivo F. nucleatum loading, and thus implements treatment and prevention of various F. nucleatum-related diseases. In addition, the polypeptide has advantages such as having a rapid sterilization rate, being residue-free and pollution-free, and having a highly flexible molecular composition and low immunogenicity.
Inventors:
ZHAO WENJING (CN)
CHOU SHULI (CN)
MOU XIANGYU (CN)
CHOU SHULI (CN)
MOU XIANGYU (CN)
Application Number:
PCT/CN2023/100589
Publication Date:
December 21, 2023
Filing Date:
June 16, 2023
Export Citation:
Assignee:
UNIV SUN YAT SEN (CN)
International Classes:
A61K38/08; C07K7/06; A61K38/10; A61P1/00; C07K1/04; C07K7/08
Domestic Patent References:
| WO2021220011A1 | 2021-11-04 |
Foreign References:
| CN114989254A | 2022-09-02 | |||
| CN107746429A | 2018-03-02 | |||
| CN103923189A | 2014-07-16 | |||
| CN111423492A | 2020-07-17 | |||
| CN108276485A | 2018-07-13 |
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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