Title:
POLYPEPTIDE DIMERS FOR THE TREATMENT OF SYSTEMIC SCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2024/011946
Kind Code:
A1
Abstract:
Provided is a polypeptide dimer for the treatment of systemic sclerosis.
Inventors:
ZOU HEJIAN (CN)
XUE YU (CN)
WAN WEIGUO (CN)
YE WENJING (CN)
WANG QIAN (CN)
GUO WENYU (CN)
XUE YU (CN)
WAN WEIGUO (CN)
YE WENJING (CN)
WANG QIAN (CN)
GUO WENYU (CN)
Application Number:
PCT/CN2023/082966
Publication Date:
January 18, 2024
Filing Date:
March 22, 2023
Export Citation:
Assignee:
I MAB BIOPHARMA HANGZHOU CO LTD (CN)
International Classes:
C07K14/705; A61K38/16; A61P17/00; C07K14/715; C07K19/00
Foreign References:
| US20180282396A1 | 2018-10-04 | |||
| US20100028367A1 | 2010-02-04 | |||
| US20170320932A1 | 2017-11-09 | |||
| US20210155687A1 | 2021-05-27 | |||
| CN106860855A | 2017-06-20 |
Other References:
CARDONEANU ANCA, BURLUI ALEXANDRA MARIA, MACOVEI LUANA ANDREEA, BRATOIU IOANA, RICHTER PATRICIA, REZUS ELENA: "Targeting Systemic Sclerosis from Pathogenic Mechanisms to Clinical Manifestations: Why IL-6?", BIOMEDICINES, MDPI, BASEL, vol. 10, no. 2, 29 January 2022 (2022-01-29), Basel , pages 318, XP093129537, ISSN: 2227-9059, DOI: 10.3390/biomedicines10020318
PAUL BARAN, SELINA HANSEN, GEORG H. WAETZIG, MOHAMMAD AKBARZADEH, LARISSA LAMERTZ, HEINRICH J. HUBER, M. REZA AHMADIAN, JENS M. MO: "The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 293, no. 18, 4 May 2018 (2018-05-04), US , pages 6762 - 6775, XP055666698, ISSN: 0021-9258, DOI: 10.1074/jbc.RA117.001163
PAUL BARAN, SELINA HANSEN, GEORG H. WAETZIG, MOHAMMAD AKBARZADEH, LARISSA LAMERTZ, HEINRICH J. HUBER, M. REZA AHMADIAN, JENS M. MO: "The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 293, no. 18, 4 May 2018 (2018-05-04), US , pages 6762 - 6775, XP055666698, ISSN: 0021-9258, DOI: 10.1074/jbc.RA117.001163
Attorney, Agent or Firm:
SHANGHAI HUIYE LAW FIRM (CN)
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