Title:
POLYPEPTIDE FROM A HDM2 PROTEIN SPECIFIC MURINE ALPHA / beta T-CELL RECEPTORS, NUCLEIC ACIDS CODING FOR THE ABOVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO2002070552
Kind Code:
A8
Abstract:
The invention relates to polypeptides from a murine alpha / beta T-cell receptor, mediating a hdm2 protein-specific T-cell response, or functional variants or parts thereof, or nucleic acids coding for the above, functional variants, or parts thereof. The effect of the above is that hdm2 protein-expressing cells are recognised by t-cells provided with said genes, cytokines are expressed and a t-cell-induced lysis and/or apoptosis of tumour- or leukaemic-cells is induced.
Inventors:
STANISLAWSKI THOMAS (DE)
THEOBALT MATTHIAS (DE)
VOSS HOLGER (DE)
THEOBALT MATTHIAS (DE)
VOSS HOLGER (DE)
Application Number:
PCT/EP2002/002187
Publication Date:
October 10, 2002
Filing Date:
February 28, 2002
Export Citation:
Assignee:
STANISLAWSKI THOMAS (DE)
THEOBALT MATTHIAS (DE)
VOSS HOLGER (DE)
THEOBALT MATTHIAS (DE)
VOSS HOLGER (DE)
International Classes:
G01N33/15; A61K31/7088; A61K35/26; A61K38/00; A61K39/395; A61K48/00; C07K14/705; C07K14/725; C07K16/28; C07K19/00; C12N5/10; C12N15/09; C12P21/08; C12Q1/02; (IPC1-7): C07K14/47
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