Title:
POLYROTAXANE HAVING HYDROXY GROUP OR SULFO GROUP
Document Type and Number:
WIPO Patent Application WO/2022/113944
Kind Code:
A1
Abstract:
The present invention provides a coating agent which contains polyrotaxane represented by formula (1), and is for promoting the osteoblast differentiation and/or adipose differentiation of mesenchymal stem cells. [In the formula, R1 is a hydrogen atom or a methyl group, m is 1-2,000, and n is 10-500, and formula (2) is cyclodextrin in which at least one hydroxyl group is modified with a group represented by -X-Y, where X is a divalent organic group and Y is a hydroxyl group or a sulfo group.]
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Inventors:
AOYAMA RURIKO (JP)
ARISAKA YOSHINORI (JP)
YUI NOBUHIKO (JP)
IWATA TAKANORI (JP)
YODA TETSUYA (JP)
HAKARIYA MASAHIRO (JP)
MASUDA HIROKI (JP)
ARISAKA YOSHINORI (JP)
YUI NOBUHIKO (JP)
IWATA TAKANORI (JP)
YODA TETSUYA (JP)
HAKARIYA MASAHIRO (JP)
MASUDA HIROKI (JP)
Application Number:
PCT/JP2021/042832
Publication Date:
June 02, 2022
Filing Date:
November 22, 2021
Export Citation:
Assignee:
DENKA COMPANY LTD (JP)
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
International Classes:
C12N11/02; C12M3/00; C12N5/0775
Other References:
ARISAKA YOSHINORI, YUI NOBUHIKO: "Tethered bone morphogenetic protein-2 onto sulfonated-polyrotaxane based surfaces promotes osteogenic differentiation of MC3T3-E1 cells", JOURNAL OF BIOMATERIALS SCIENCE. POLYMER ED., vol. 28, no. 10-12, 13 August 2017 (2017-08-13), pages 974 - 985, XP009536866, DOI: 10.1080/09205063.2017.1319095
RAJENDRAN ARUN KUMAR, ARISAKA YOSHINORI, ISEKI SACHIKO, YUI NOBUHIKO: "Sulfonated Polyrotaxane Surfaces with Basic Fibroblast Growth Factor Alter the Osteogenic Potential of Human Mesenchymal Stem Cells in Short-Term Culture", HHS AUTHOR MANUSCRIPTS, vol. 5, no. 11, 11 November 2019 (2019-11-11), US , pages 5652 - 5659, XP055869712, DOI: 10.1021/acsbiomaterials.8b01343
ATSUSHI TAMURA, HAJIME TANAKA, NOBUHIKO YUI: "Supramolecular flower micelle formation of polyrotaxane-containing triblock copolymers prepared from macro-chain transfer agents bearing molecular hooks", POLYMER CHEMISTRY, vol. 5, no. 15, 1 January 2014 (2014-01-01), pages 4511, XP055363882, ISSN: 1759-9954, DOI: 10.1039/c4py00379a
SEO JI-HUN, KAKINOKI SACHIRO, YAMAOKA TETSUJI, YUI NOBUHIKO: "Directing Stem Cell Differentiation by Changing the Molecular Mobility of Supramolecular Surfaces", ADVANCED HEALTHCARE MATERIALS, vol. 4, no. 2, 1 January 2015 (2015-01-01), DE , pages 215 - 222, XP055934942, ISSN: 2192-2640, DOI: 10.1002/adhm.201400173
CELL, vol. 126, 2006, pages 677 - 689
NATURE REVIEWS MATERIALS, vol. 5, 2020, pages 686 - 705
JI-HUN SEO ET AL., ADV. HEALTHCARE MATER., vol. 4, 2015, pages 215 - 222
SOFT MATTER, vol. 8, 2012, pages 5477 - 5485
J. BIOMATER. SCI. POLYM. ED., vol. 28, 2017, pages 986 - 999
ACS BIOMATER. SCI. ENG., vol. 4, 2018, pages 1591 - 1597
RAJENDRAN ARUN KUMAR, ARISAKA YOSHINORI, ISEKI SACHIKO, YUI NOBUHIKO: "Sulfonated Polyrotaxane Surfaces with Basic Fibroblast Growth Factor Alter the Osteogenic Potential of Human Mesenchymal Stem Cells in Short-Term Culture", HHS AUTHOR MANUSCRIPTS, vol. 5, no. 11, 11 November 2019 (2019-11-11), US , pages 5652 - 5659, XP055869712, DOI: 10.1021/acsbiomaterials.8b01343
ATSUSHI TAMURA, HAJIME TANAKA, NOBUHIKO YUI: "Supramolecular flower micelle formation of polyrotaxane-containing triblock copolymers prepared from macro-chain transfer agents bearing molecular hooks", POLYMER CHEMISTRY, vol. 5, no. 15, 1 January 2014 (2014-01-01), pages 4511, XP055363882, ISSN: 1759-9954, DOI: 10.1039/c4py00379a
SEO JI-HUN, KAKINOKI SACHIRO, YAMAOKA TETSUJI, YUI NOBUHIKO: "Directing Stem Cell Differentiation by Changing the Molecular Mobility of Supramolecular Surfaces", ADVANCED HEALTHCARE MATERIALS, vol. 4, no. 2, 1 January 2015 (2015-01-01), DE , pages 215 - 222, XP055934942, ISSN: 2192-2640, DOI: 10.1002/adhm.201400173
CELL, vol. 126, 2006, pages 677 - 689
NATURE REVIEWS MATERIALS, vol. 5, 2020, pages 686 - 705
JI-HUN SEO ET AL., ADV. HEALTHCARE MATER., vol. 4, 2015, pages 215 - 222
SOFT MATTER, vol. 8, 2012, pages 5477 - 5485
J. BIOMATER. SCI. POLYM. ED., vol. 28, 2017, pages 986 - 999
ACS BIOMATER. SCI. ENG., vol. 4, 2018, pages 1591 - 1597
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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