Title:
POLYSACCHARIDE AND DERIVATIVES THEREOF, SHOWING AFFINITY TO FICOLIN-3, METHOD OF PREPARATION AND USE
Document Type and Number:
WIPO Patent Application WO/2011/155859
Kind Code:
A3
Abstract:
The invention relates to bacterial lipopolysaccharide and its components, especially native and chemically modified polysaccharides isolated from Hafnia alvei lipopolysaccharides, as well as conjugates of these polysaccharides with carriers and methods for their preparation and methods to use of these substances as ligands for human ficolin-3.
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Inventors:
LUKASIEWICZ JOLANTA (PL)
SWIERZKO ANNA (PL)
CEDZYNSKI MACIEJ (PL)
LUGOWSKI CZESLAW (PL)
MACIEJEWSKA ANNA (PL)
JACHYMEK WOJCIECH (PL)
NIEDZIELA TOMASZ (PL)
SWIERZKO ANNA (PL)
CEDZYNSKI MACIEJ (PL)
LUGOWSKI CZESLAW (PL)
MACIEJEWSKA ANNA (PL)
JACHYMEK WOJCIECH (PL)
NIEDZIELA TOMASZ (PL)
Application Number:
PCT/PL2011/050024
Publication Date:
February 23, 2012
Filing Date:
June 11, 2011
Export Citation:
Assignee:
INST IMMUNOLOGII I TERAPII DOSWIADCZALNEJ PAN (PL)
INST BIOLOG MEDYCZNEJ POLSKIEJ AKADEMII NAUK (PL)
LUKASIEWICZ JOLANTA (PL)
SWIERZKO ANNA (PL)
CEDZYNSKI MACIEJ (PL)
LUGOWSKI CZESLAW (PL)
MACIEJEWSKA ANNA (PL)
JACHYMEK WOJCIECH (PL)
NIEDZIELA TOMASZ (PL)
INST BIOLOG MEDYCZNEJ POLSKIEJ AKADEMII NAUK (PL)
LUKASIEWICZ JOLANTA (PL)
SWIERZKO ANNA (PL)
CEDZYNSKI MACIEJ (PL)
LUGOWSKI CZESLAW (PL)
MACIEJEWSKA ANNA (PL)
JACHYMEK WOJCIECH (PL)
NIEDZIELA TOMASZ (PL)
International Classes:
G01N33/53; C08B37/00
Other References:
TSUJIMURA MITSUSHI ET AL: "Detection of serum thermolabile beta-2 macroglycoprotein (Hakata antigen) by enzyme-linked immunosorbent assay using polysaccharide produced by Aerococcus viridans", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 8, no. 2, 1 January 2001 (2001-01-01), pages 454 - 459, XP002593298, ISSN: 1071-412X, DOI: 10.1128/CDLI.8.2.454-459.2001
TSUJIMURA MITSUSHI ET AL: "Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth.", CLINICA CHIMICA ACTA, vol. 325, no. 1-2, November 2002 (2002-11-01), pages 139 - 146, XP002665675, ISSN: 0009-8981
KATZENELLENBOGEN E ET AL: "Structures of the biological repeating units in the O-chain polysaccharides of Hafnia alvei strains having a typical lipopolysaccharide outer core region", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, ELSEVIER SCIENCE B.V., AMSTERDAM, NL, vol. 45, no. 2, 1 August 2005 (2005-08-01), pages 269 - 278, XP025316707, ISSN: 0928-8244, [retrieved on 20050801], DOI: 10.1016/J.FEMSIM.2005.05.003
HEIN E ET AL: "Development of a functional assay specific for Ficolin-3 mediated complement activation", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 46, no. 14, 1 September 2009 (2009-09-01), pages 2843, XP026438448, ISSN: 0161-5890, [retrieved on 20090806]
TSUJIMURA MITSUSHI ET AL: "Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth.", CLINICA CHIMICA ACTA, vol. 325, no. 1-2, November 2002 (2002-11-01), pages 139 - 146, XP002665675, ISSN: 0009-8981
KATZENELLENBOGEN E ET AL: "Structures of the biological repeating units in the O-chain polysaccharides of Hafnia alvei strains having a typical lipopolysaccharide outer core region", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, ELSEVIER SCIENCE B.V., AMSTERDAM, NL, vol. 45, no. 2, 1 August 2005 (2005-08-01), pages 269 - 278, XP025316707, ISSN: 0928-8244, [retrieved on 20050801], DOI: 10.1016/J.FEMSIM.2005.05.003
HEIN E ET AL: "Development of a functional assay specific for Ficolin-3 mediated complement activation", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 46, no. 14, 1 September 2009 (2009-09-01), pages 2843, XP026438448, ISSN: 0161-5890, [retrieved on 20090806]
Attorney, Agent or Firm:
WITEK, Rafał (Witek Śnieżko & Partner, ul. Rudolfa Weigla 12 Wrocław, PL)
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