Title:
POLYSUBSTITUTED BENZENE PD-L1 INHIBITOR, COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/006019
Kind Code:
A1
Abstract:
Disclosed in the present invention are a polysubstituted benzene PD-L1 inhibitor, a composition and the use thereof. The compound has a structure as represented by general formula (I). The inventor of the present invention confirmed by means of an experiment that the compound of the present invention exhibits a strong PD-1/PD-L1 blocking activity and a significant PD-L1 occupancy activity, and can reverse a PD-L1-inhibited T cell function. Moreover, the compound of the present invention can be orally absorbed, has a good pharmacokinetic property, and has a good anti-tumor inhibitory activity in vivo. Thus, the compound of the present invention can be used alone or in combination with other drugs in the treatment of diseases, disorders or conditions which would benefit from the inhibition of PD1 or PD-L1 activity, including infectious diseases, immune diseases, inflammatory diseases and cancers.
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Inventors:
WU YIZHE (CN)
ZHOU XINGLU (CN)
LIU XINGGUO (CN)
HU MIAO (CN)
ZHU JIANRONG (CN)
ZHOU XINGLU (CN)
LIU XINGGUO (CN)
HU MIAO (CN)
ZHU JIANRONG (CN)
Application Number:
PCT/CN2022/108538
Publication Date:
February 02, 2023
Filing Date:
July 28, 2022
Export Citation:
Assignee:
HANGZHOU HEALZEN THERAPEUTICS CO LTD (CN)
International Classes:
C07D471/04; A61K31/423; A61P37/00; A61P37/04; C07D413/14
Domestic Patent References:
| WO2020156323A1 | 2020-08-06 |
Foreign References:
| CN110582493A | 2019-12-17 | |||
| CN110267953A | 2019-09-20 | |||
| CN112135824A | 2020-12-25 |
Attorney, Agent or Firm:
HANGZHOU ZHIXIAN PATENT AGENCY (CN)
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