Title:
POLYURETHANE HIGH-MOLECULAR POLYMER AND PREPARATION METHOD THEREFOR, POLYURETHANE HIGH-MOLECULAR POLYMER HYDROGEL, KIT, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/221870
Kind Code:
A1
Abstract:
Provided in the present invention are a polyurethane high-molecular polymer and a preparation method therefor, a polyurethane high-molecular polymer hydrogel, a kit, and the use thereof. The polyurethane high-molecular polymer is obtained by polymerizing prepolymerized polyethylene glycol, prepolymerized polypropylene glycol, prepolymerized polycaprolactone and a conjugating agent, wherein the conjugating agent has a structure as shown in formula (I). In the present invention, the polymer has a better biocompatibility and a lower toxicity; and when the polymer is subsequently prepared into a hydrogel for use, the characteristics of the syringeability, the gelation temperature, the modulus of elasticity at 37°C, the kinematic viscosity, the density, the surface tension, the light transmittance, the diopter, etc., of the hydrogel are all closer to those of a vitreous body. Therefore, when used as a vitreous substitute, the hydrogel has a higher substituting performance and better use effects.
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Inventors:
XIE QIN (CN)
ZHANG YU (CN)
ZHANG YU (CN)
Application Number:
PCT/CN2023/093621
Publication Date:
November 23, 2023
Filing Date:
May 11, 2023
Export Citation:
Assignee:
ZHEJIANG OCUARMOR MEDTECH CO LTD (CN)
International Classes:
C08G18/48; A61L27/18; C08J3/075
Foreign References:
| CN114907540A | 2022-08-16 | |||
| CN114907584A | 2022-08-16 | |||
| CN111617314A | 2020-09-04 | |||
| CN101654508A | 2010-02-24 | |||
| US5100992A | 1992-03-31 |
Other References:
LIU ZENGPING; LIOW SING SHY; LAI SIEW LI; ALLI-SHAIK ASFA; HOLDER GRAHAM E.; PARIKH BHAV HARSHAD; KRISHNAKUMAR SUBRAMANIAN; LI ZIB: "Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade", NATURE BIOMEDICAL ENGINEERING, NATURE PUBLISHING GROUP UK, LONDON, vol. 3, no. 8, 8 April 2019 (2019-04-08), London , pages 598 - 610, XP036854651, DOI: 10.1038/s41551-019-0382-7
LIU QING-FENG, FENG SHENG-SHAN, XU SHUN-HONG: "Research progress of medical biodegradable polyurethane", CHINA ELASTOMETRICS., vol. 17, no. 4, 25 August 2007 (2007-08-25), pages 63 - 65, XP093108987, DOI: 1005-3174(2007)04-0063-06
LIU QING-FENG, FENG SHENG-SHAN, XU SHUN-HONG: "Research progress of medical biodegradable polyurethane", CHINA ELASTOMETRICS., vol. 17, no. 4, 25 August 2007 (2007-08-25), pages 63 - 65, XP093108987, DOI: 1005-3174(2007)04-0063-06
Attorney, Agent or Firm:
KANGXIN PARTNERS , P.C. (CN)
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