Title:
POROUS AEROGEL SCAFFOLD, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/087523
Kind Code:
A1
Abstract:
Disclosed in the present invention are a porous aerogel scaffold, and a preparation method therefor and an application thereof. The preparation method comprises: adding a photoinitiator and polyethylene glycol diacrylate into a buffer solution, heating for dissolution, uniformly mixing, then adding Pluronic F127 into the mixture, and letting same stand at a low temperature to obtain an aerogel scaffold material; and printing a hydrogel scaffold by means of 3D printing technology, carrying out ultraviolet irradiation for cross-linking to form a three-dimensional scaffold having a stable structure, carrying out low-temperature soaking to remove the Pluronic F127, and freeze drying to obtain a porous aerogel scaffold. The Pluronic F127 is used as a sacrificial material, and after 3D printing of the hydrogel scaffold is completed, the Pluronic F127 is removed; a porous structure can be formed in the scaffold by means of freeze drying technology; it is beneficial to the survival, growth and proliferation of cells during three-dimensional culture.
Inventors:
HUANG CHUANZHEN (CN)
WANG ZHICHAO (CN)
LIU HANLIAN (CN)
YAO PENG (CN)
WANG WEI (CN)
WANG ZHEN (CN)
XU LONGHUA (CN)
HUANG SHUIQUAN (CN)
WANG JUN (CN)
ZHU HONGTAO (CN)
ZOU BIN (CN)
WANG ZHICHAO (CN)
LIU HANLIAN (CN)
YAO PENG (CN)
WANG WEI (CN)
WANG ZHEN (CN)
XU LONGHUA (CN)
HUANG SHUIQUAN (CN)
WANG JUN (CN)
ZHU HONGTAO (CN)
ZOU BIN (CN)
Application Number:
PCT/CN2022/071218
Publication Date:
May 25, 2023
Filing Date:
January 11, 2022
Export Citation:
Assignee:
UNIV SHANDONG (CN)
UNIV YANSHAN (CN)
UNIV YANSHAN (CN)
International Classes:
C08J9/26; B33Y70/00; C08J3/075; C08J3/28; C08J9/28; C12N5/00
Domestic Patent References:
| WO2019074314A1 | 2019-04-18 |
Foreign References:
| CN109124821A | 2019-01-04 | |||
| CN112999425A | 2021-06-22 | |||
| CN108888803A | 2018-11-27 | |||
| CN113290844A | 2021-08-24 | |||
| CN111450324A | 2020-07-28 |
Other References:
TANG AIMIN, LI JING, LI JIAO, ZHAO SHAN, LIU WANGYU, LIU TINGTING, WANG JUFANG, LIU YINGYAO: "Nanocellulose/PEGDA aerogel scaffolds with tunable modulus prepared by stereolithography for three-dimensional cell culture", JOURNAL OF BIOMATERIALS SCIENCE. POLYMER EDITION., VSP, UTRECHT., NL, vol. 30, no. 10, 3 July 2019 (2019-07-03), NL , pages 797 - 814, XP093067864, ISSN: 0920-5063, DOI: 10.1080/09205063.2019.1602904
TANG AIMIN, WANG QINWEN, ZHAO SHAN, LIU WANGYU: "Fabrication of nanocellulose/PEGDA hydrogel by 3D printing", RAPID PROTOTYPING JOURNAL, vol. 24, no. 8, 1 January 2018 (2018-01-01), pages 1265 - 1271, XP009545631, DOI: 10.1108/RPJ-03-2016-0049
TANG AIMIN, WANG QINWEN, ZHAO SHAN, LIU WANGYU: "Fabrication of nanocellulose/PEGDA hydrogel by 3D printing", RAPID PROTOTYPING JOURNAL, vol. 24, no. 8, 1 January 2018 (2018-01-01), pages 1265 - 1271, XP009545631, DOI: 10.1108/RPJ-03-2016-0049
Attorney, Agent or Firm:
JINAN SHENGDA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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