Title:
PREVENTIVES/REMEDIES FOR PORTAL HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2002/034263
Kind Code:
A1
Abstract:
Preventives/remedies for portal hypertension containing compounds represented by the general formula (I), salts thereof or prodrugs of the same are provided. In said formula, R?1¿ represents a group capable of forming an anion; X represents a bond or a spacer; n is an integer of 1 or 2; the ring A is an optionally substituted benzene ring; R?2¿ represents a group capable of forming an anion; and R?3¿ represents optionally substituted hydrocarbyl which may bonded via a hetero atom. These drugs are sufficiently excellent as medicines, since they have favorable preventive and therapeutic effects on portal hypertension without any side effect.
Inventors:
WATANABE TOSHIFUMI (JP)
KUSUMOTO KEIJI (JP)
OJIMA MAMI (JP)
KUSUMOTO KEIJI (JP)
OJIMA MAMI (JP)
Application Number:
PCT/JP2001/009311
Publication Date:
May 02, 2002
Filing Date:
October 24, 2001
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
WATANABE TOSHIFUMI (JP)
KUSUMOTO KEIJI (JP)
OJIMA MAMI (JP)
WATANABE TOSHIFUMI (JP)
KUSUMOTO KEIJI (JP)
OJIMA MAMI (JP)
International Classes:
A61K9/16; A61K9/20; A61K9/48; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/4245; A61K31/433; A61P9/12; A61P43/00; C07D403/10; (IPC1-7): A61K31/41; A61K31/4178; A61K31/4184; A61K31/4245; A61K31/433; A61K45/00; A61P9/12; A61P43/00
Domestic Patent References:
| WO1992019211A2 | 1992-11-12 |
Foreign References:
| EP0628313A1 | 1994-12-14 | |||
| EP0603001A1 | 1994-06-22 | |||
| EP0459136A1 | 1991-12-04 | |||
| JP2001302512A | 2001-10-31 | |||
| JP2001316296A | 2001-11-13 |
Other References:
SCHNEIDER A.W. ET AL., HEPATOLOGY, vol. 29, no. 2, 1999, pages 334 - 339, XP002906356
ROCKEY D.C. ET AL., HEPATOLOGY, vol. 24, no. 1, 1996, pages 233 - 240, XP002906357
CHEMICAL ABSTRACTS, vol. 129, Columbus, Ohio, US; abstract no. 329161, XP002906358
See also references of EP 1329218A4
ROCKEY D.C. ET AL., HEPATOLOGY, vol. 24, no. 1, 1996, pages 233 - 240, XP002906357
CHEMICAL ABSTRACTS, vol. 129, Columbus, Ohio, US; abstract no. 329161, XP002906358
See also references of EP 1329218A4
Attorney, Agent or Firm:
Aoyama, Tamotsu (Shiromi 1-chome Chuo-ku, Osaka-shi Osaka, JP)
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