Title:
A POTASSIUM CHANNEL MOLECULE AND USES THEREFOR
Document Type and Number:
WIPO Patent Application WO2001066743
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acids molecules, designated TWIK-6 nucleic acid molecules, which encode novel TWIK-related potassium channel subunit molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK-6 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TWIK-6 gene has been introduced or disrupted. The invention still further provides isolated TWIK-6 proteins, fusion proteins, antigenic peptides and anti-TWIK-6 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Inventors:
CURTIS RORY A J (US)
GLUCKSMANN MARIA ALEXANDRA (US)
GLUCKSMANN MARIA ALEXANDRA (US)
Application Number:
PCT/US2001/006933
Publication Date:
March 21, 2002
Filing Date:
March 02, 2001
Export Citation:
Assignee:
MILLENNIUM PHARM INC (US)
CURTIS RORY A J (US)
GLUCKSMANN MARIA ALEXANDRA (US)
CURTIS RORY A J (US)
GLUCKSMANN MARIA ALEXANDRA (US)
International Classes:
C07K14/705; C12N15/12; (IPC1-7): C12N15/12; C07K14/705; C07K16/28; C12N15/10; C12Q1/68; G01N33/53; G01N33/68
Domestic Patent References:
| WO2001046231A2 | 2001-06-28 |
Other References:
DATABASE EMBL 28 May 1999 (1999-05-28), STRAUSBERG, R. ET AL.: "tz15g05.x1 NCI_CGAP_Ut2 Homo sapiens cDNA clone IMAGE:2288696 3' similar to TR:O35111 O35111 CTBAK. [2] TR:O54912 ;contains TAR1.t1 TAR1 repetitive element ;, mRNA sequence.", XP002177779
DATABASE EMBL 23 June 1999 (1999-06-23), STRAUSBERG, R.: "wi17h03.x1 NCI_CGAP_Co16 Homo sapiens cDNA clone IMAGE:2390549 3' similar to TR:O35111 O35111 CTBAK. [2] TR:O54912 ;contains TAR1.t1 TAR1 repetitive element ;, mRNA sequence.", XP002177780
DATABASE EMBL 26 August 1999 (1999-08-26), STRAUSBERG, R.: "wt90e12.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE:2514766 3' similar to TR:O14649 O14649 TWIK-RELATED ACID-SENSITIVE K+ CHANNEL. ;, mRNA sequence.", XP002177781
DATABASE EMBL 23 September 1999 (1999-09-23), LOVELL, J.: "Human DNA sequence from clone RP4-781B1 on chromosome 20 Contains a gene encoding the two pore potassium channel KT3.3 (LOC64181), a novel gene similar to myeloblast KIAA0237 and rat protein NIM2, two putative novel genes, 3 CpG islands, ESTs, STSs and GSSs.", XP002177782
DATABASE EMBL 20 November 2000 (2000-11-20), VEGA-SAENZ DE MIERA, E. ET AL.: "Homo sapiens two pore potassium channel KT3.3 mRNA, complete cds.", XP002177783
DATABASE EMBL 20 August 2001 (2001-08-20), KIM, D. ET AL.: "POTASSIUM CHANNEL SUBFAMILY K MEMBER 3 (ACID-SENSITIVE POTASSIUM CHANNEL PROTEIN TASK) (TWIK-RELATED ACID-SENSITIVE K+ CHANNEL) (CARDIAC TWO-PORE BACKGROUND K+ CHANNEL) (CTBAK-1).", XP002177784
KIM DONGHEE ET AL: "TASK-5, a new member of the tandem-pore K+ channel family.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 284, no. 4, 22 June 2001 (2001-06-22), pages 923 - 930, XP002177778, ISSN: 0006-291X
DATABASE EMBL 23 June 1999 (1999-06-23), STRAUSBERG, R.: "wi17h03.x1 NCI_CGAP_Co16 Homo sapiens cDNA clone IMAGE:2390549 3' similar to TR:O35111 O35111 CTBAK. [2] TR:O54912 ;contains TAR1.t1 TAR1 repetitive element ;, mRNA sequence.", XP002177780
DATABASE EMBL 26 August 1999 (1999-08-26), STRAUSBERG, R.: "wt90e12.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE:2514766 3' similar to TR:O14649 O14649 TWIK-RELATED ACID-SENSITIVE K+ CHANNEL. ;, mRNA sequence.", XP002177781
DATABASE EMBL 23 September 1999 (1999-09-23), LOVELL, J.: "Human DNA sequence from clone RP4-781B1 on chromosome 20 Contains a gene encoding the two pore potassium channel KT3.3 (LOC64181), a novel gene similar to myeloblast KIAA0237 and rat protein NIM2, two putative novel genes, 3 CpG islands, ESTs, STSs and GSSs.", XP002177782
DATABASE EMBL 20 November 2000 (2000-11-20), VEGA-SAENZ DE MIERA, E. ET AL.: "Homo sapiens two pore potassium channel KT3.3 mRNA, complete cds.", XP002177783
DATABASE EMBL 20 August 2001 (2001-08-20), KIM, D. ET AL.: "POTASSIUM CHANNEL SUBFAMILY K MEMBER 3 (ACID-SENSITIVE POTASSIUM CHANNEL PROTEIN TASK) (TWIK-RELATED ACID-SENSITIVE K+ CHANNEL) (CARDIAC TWO-PORE BACKGROUND K+ CHANNEL) (CTBAK-1).", XP002177784
KIM DONGHEE ET AL: "TASK-5, a new member of the tandem-pore K+ channel family.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 284, no. 4, 22 June 2001 (2001-06-22), pages 923 - 930, XP002177778, ISSN: 0006-291X
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