Title:
POWDER, WOUND-COVERING MATERIAL, ADHESION PREVENTION MATERIAL, HEMOSTATIC MATERIAL, AND PRODUCTION METHOD FOR POWDER
Document Type and Number:
WIPO Patent Application WO/2020/137903
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a powder that has excellent adhesive strength to biological tissue when applied to a wound-covering material or the like. The present invention also addresses the problem of providing a wound-covering material and an adhesion prevention material. The powder contains particles containing a crosslinked gelatin derivative, wherein the gelatin derivative has a structure represented by formula (1): GtlnNH-L-CHR1R2 (in the formula, Gltn represents a residue of gelatin, L represents a single bond or a divalent linking group, R1 represents a hydrocarbon group having 1-20 carbon atoms, and R2 represents a hydrogen atom or a hydrocarbon group having 1-20 carbon atoms), the particles have an average sphericity of 1.45 or less, and the standard deviation of the sphericity of the particles is 0.25 or less.
Inventors:
TAGUCHI TETSUSHI (JP)
Application Number:
PCT/JP2019/050157
Publication Date:
July 02, 2020
Filing Date:
December 20, 2019
Export Citation:
Assignee:
NAT INST MATERIALS SCIENCE (JP)
International Classes:
C07K14/78; A61K9/14; A61K9/19; A61K47/42; A61L15/32; A61L15/64
Domestic Patent References:
| WO2017126390A1 | 2017-07-27 | |||
| WO2019045081A1 | 2019-03-07 | |||
| WO2018079538A1 | 2018-05-03 |
Foreign References:
| JP2019051189A | 2019-04-04 | |||
| JP2010083788A | 2010-04-15 | |||
| JP2007231225A | 2007-09-13 |
Other References:
AKIHIRO NISHIGUCHI, TETSUSHI TAGUCHI: "1B-06: Development of multifunctional wound healing particles toward digestive system cancer therapy", PREPRINTS OF THE ANNUAL MEETING OF THE JAPANESE SOCIETY FOR BIOMATERIALS, vol. 40, November 2018 (2018-11-01), pages 85, XP009522257
AKIHIRO NISHIGUCHI, TETSUSHI TAGUCHI: "Colloidal wound dressing with high tissue adhensiveness for digestive system cancer therapy", PROGRAMME 29TH ANNUAL CONGRESS OF THE EUROPEAN SOCIETY FOR BIOMATERIALS; 9–13 SEPTEMBER 2018 | MAASTRICHT, THE NETHERLANDS, vol. 29th, November 2018 (2018-11-01), pages 184 - 185, XP009522258
Y. MIZUNO, R. MIZUTA ,M. HASHIZUME ,T. TAGUCHI: "Enhanced sealing strength of a hydrophobically-modified Alaska pollock gelatin-based sealant.", BIOMATERIALS SCIENCE, vol. 5, no. 5, 15 March 2017 (2017-03-15), pages 982 - 989, XP055721903, ISSN: 2047-4830, DOI: 10.1039/C6BM00829A
AKIHIRO NISHIGUCHI, FUMISATO SASAKI, HIDEHITO MAEDA, MASAYUKI KABAYAMA, AKIO IDO, TETSUSHI TAGUCHI: "Multifunctional hydrophobized microparticles for accelerated wound healing after endoscopic submucosal dissection", SMALL, vol. 15, no. 35, 15 July 2019 (2019-07-15), pages 1 - 9, XP055721912, ISSN: 1613-6810, DOI: 10.1002/smll.201901566
AKIHIRO NISHIGUCHI, TETSUSHI TAGUCHI: "Colloidal wound dressing with high tissue adhensiveness for digestive system cancer therapy", PROGRAMME 29TH ANNUAL CONGRESS OF THE EUROPEAN SOCIETY FOR BIOMATERIALS; 9–13 SEPTEMBER 2018 | MAASTRICHT, THE NETHERLANDS, vol. 29th, November 2018 (2018-11-01), pages 184 - 185, XP009522258
Y. MIZUNO, R. MIZUTA ,M. HASHIZUME ,T. TAGUCHI: "Enhanced sealing strength of a hydrophobically-modified Alaska pollock gelatin-based sealant.", BIOMATERIALS SCIENCE, vol. 5, no. 5, 15 March 2017 (2017-03-15), pages 982 - 989, XP055721903, ISSN: 2047-4830, DOI: 10.1039/C6BM00829A
AKIHIRO NISHIGUCHI, FUMISATO SASAKI, HIDEHITO MAEDA, MASAYUKI KABAYAMA, AKIO IDO, TETSUSHI TAGUCHI: "Multifunctional hydrophobized microparticles for accelerated wound healing after endoscopic submucosal dissection", SMALL, vol. 15, no. 35, 15 July 2019 (2019-07-15), pages 1 - 9, XP055721912, ISSN: 1613-6810, DOI: 10.1002/smll.201901566
Attorney, Agent or Firm:
ASAMURA PATENT OFFICE, P.C. (JP)
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