Title:
PPAR LIGAND
Document Type and Number:
WIPO Patent Application WO/2011/001913
Kind Code:
A1
Abstract:
Disclosed is a ligand for peroxisome proliferator-activated receptor (PPAR) which originates in a safe food material. Specifically disclosed is a PPAR ligand which comprises, as the active ingredient, a Luffa acutangula L. extract or a novel compound contained in the Luffa acutangula L. extract. This PPAR ligand is efficacious in preventing and/or ameliorating obesity and obesity-related disorders such as insulin resistance, hyperlipemia, hypertension, diabetes, etc.
Inventors:
MAEDA MITSURU (JP)
OGURA KYOICHI (JP)
MAEJIMA KAZUHIRO (JP)
OGURA KYOICHI (JP)
MAEJIMA KAZUHIRO (JP)
Application Number:
PCT/JP2010/060834
Publication Date:
January 06, 2011
Filing Date:
June 25, 2010
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
NIPPON SHINYAKU CO LTD (JP)
MAEDA MITSURU (JP)
OGURA KYOICHI (JP)
MAEJIMA KAZUHIRO (JP)
NIPPON SHINYAKU CO LTD (JP)
MAEDA MITSURU (JP)
OGURA KYOICHI (JP)
MAEJIMA KAZUHIRO (JP)
International Classes:
A61K36/42; A23L1/30; A23L2/52; A61K31/343; A61K31/7048; A61P3/04; A61P3/06; A61P3/10; A61P9/12; A61P43/00; C07D307/79; C07H13/10
Domestic Patent References:
| WO2000053563A1 | 2000-09-14 | |||
| WO2009064251A1 | 2009-05-22 |
Foreign References:
| JP2008184459A | 2008-08-14 |
Other References:
DANIEL C. BERRY AND NOA NOY: "All-trans-Retinoic Acid Represses Obesity and Insulin Resistance by Activating both Peroxisome Proliferation-Activated Receptor beta/ and Retinoic Acid Receptor", MOL. CELL BIOL., vol. 29, no. 12, June 2009 (2009-06-01), pages 3286 - 3296
JOURNAL OF BLOOD PRESSURE, vol. 7, no. 3, 2000, pages 239 - 243
JOHANNES VON LINTIG AND KLAUS VOGT: "Filling the Gap in Vitamin A Research: MOLECULAR IDENTIFICATION OF AN ENZYME CLEAVING BETA-CAROTENE TO RETINAL", J. BIOL. CHEM., vol. 275, no. 16, 21 April 2000 (2000-04-21), pages 11915 - 11920
KANDLAKUNTA; RAJENDRAN B; THINGNGANING A; L: "Carotene content of some common (cereals, pulses, vegetables, spices and condiments) and unconventional sources of plant origin", FOOD CHEM., vol. 106, 2008, pages 85 - 89, XP022219837
H. J. C. F. NELIS, A. P. DE LEENHEER: "Isocratic nonaqueous reversed-phase liquid chromatography of carotenoids", ANAL. CHEM., vol. 55, 1983, pages 270 - 275
JOURNAL OF BLOOD PRESSURE, vol. 7, no. 3, 2000, pages 239 - 243
JOHANNES VON LINTIG AND KLAUS VOGT: "Filling the Gap in Vitamin A Research: MOLECULAR IDENTIFICATION OF AN ENZYME CLEAVING BETA-CAROTENE TO RETINAL", J. BIOL. CHEM., vol. 275, no. 16, 21 April 2000 (2000-04-21), pages 11915 - 11920
KANDLAKUNTA; RAJENDRAN B; THINGNGANING A; L: "Carotene content of some common (cereals, pulses, vegetables, spices and condiments) and unconventional sources of plant origin", FOOD CHEM., vol. 106, 2008, pages 85 - 89, XP022219837
H. J. C. F. NELIS, A. P. DE LEENHEER: "Isocratic nonaqueous reversed-phase liquid chromatography of carotenoids", ANAL. CHEM., vol. 55, 1983, pages 270 - 275
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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