Title:
PRAMIPEXOLE XINAFOATE AND SUSTAINED-RELEASE PHARMACEUTICAL PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/021626
Kind Code:
A1
Abstract:
Disclosed in the present invention are pramipexole xinafoate and a sustained-release pharmaceutical preparation thereof. In the present invention, after pramipexole is prepared into pramipexole xinafoate, the solubility of salts of pramipexole is reduced, and after pramipexole xinafoate is prepared into a suspension liquid preparation, the preparation has a good sustained-release effect and good stability and is suitable for large-scale production. Not only is the problem of inconvenient oral administration solved, but also a stable and effective blood drug level can be maintained for a long period of time.
Inventors:
SUN YINGJI (CN)
WANG YUGUANG (CN)
XING XIAOYAN (CN)
LIU SHANKUI (CN)
LI TIEJUN (CN)
WANG YUGUANG (CN)
XING XIAOYAN (CN)
LIU SHANKUI (CN)
LI TIEJUN (CN)
Application Number:
PCT/CN2023/081211
Publication Date:
February 01, 2024
Filing Date:
March 14, 2023
Export Citation:
Assignee:
JEWIM PHARMACEUTICAL SHANDONG CO LTD (CN)
International Classes:
C07D277/60; A61K9/00; A61K9/10; A61K31/192; A61K31/428; A61K45/06; A61P25/16
Foreign References:
| CN115260119A | 2022-11-01 | |||
| CN113730349A | 2021-12-03 | |||
| CN110327336A | 2019-10-15 | |||
| CN111212640A | 2020-05-29 | |||
| US20220040154A1 | 2022-02-10 |
Other References:
CHAUDHARY KOMAL ET AL.: "Dissolution-Controlled Salt of Pramipexole for Parenteral Administration: In Vitro Assessment and Mathematical Modeling", DISSOLUTION TECHNOLOGIES, vol. 26, no. 1, 28 February 2019 (2019-02-28), XP093111049, ISSN: 1521-298X, DOI: 10.14227/DT260119P28
Attorney, Agent or Firm:
NANJING IPLEADER INTELLECTUAL PROPERTY AGENCY FIRM (CN)
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