Title:
PRECURSORS OF LIPID METABOLISM FOR THE DIAGNOSIS AND TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2009/109798
Kind Code:
A3
Abstract:
The present invention pertains to methods for the treatment and diagnosis of cancer employing prodrugs for targeting of lipid metabolism comprising either a detectable label or a therapeutic residue. The invention is based on the finding that the present prodrugs are specifically enriched in tumor tissue, in which they may be detected by suitable imaging techniques. Alternatively, a prodrug comprising a therapeutic residue, such as a suitable radioactive residue, may be used for the treatment of cancer.
Inventors:
RESKE SVEN NORBERT (DE)
ZLATOPOLSKIY BORIS (DE)
SOLBACH CHRISTOPH (DE)
ZLATOPOLSKIY BORIS (DE)
SOLBACH CHRISTOPH (DE)
Application Number:
PCT/IB2008/000542
Publication Date:
October 28, 2010
Filing Date:
March 07, 2008
Export Citation:
Assignee:
UNIV ULM (DE)
RESKE SVEN NORBERT (DE)
ZLATOPOLSKIY BORIS (DE)
SOLBACH CHRISTOPH (DE)
RESKE SVEN NORBERT (DE)
ZLATOPOLSKIY BORIS (DE)
SOLBACH CHRISTOPH (DE)
International Classes:
A61K49/10
Domestic Patent References:
| WO2005067388A2 | 2005-07-28 | |||
| WO2002000265A1 | 2002-01-03 | |||
| WO2008036691A2 | 2008-03-27 |
Other References:
KIM DAE-KEE ET AL: "Synthesis and antitumor activity of a series of (2-substituted-4,5-bis(aminomethyl)-1,3-dioxolane)platinum(II) complexes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, no. 10, 1994, pages 1471 - 1485, XP002578049, ISSN: 0022-2623
YOSHIMOTO M ET AL: "Characterization of acetate metabolism in tumor cells in relation to cell proliferation: Acetate metabolism in tumor cells", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY, US LNKD- DOI:10.1016/S0969-8051(00)00195-5, vol. 28, no. 2, 1 February 2001 (2001-02-01), pages 117 - 122, XP004233295, ISSN: 0969-8051
PONDE DATTA E ET AL: "F-18-fluoroacetate: A potential acetate analog for prostate tumor imaging - In vivo evaluation of F-18-fluoroacetate versus C-11-acetate", JOURNAL OF NUCLEAR MEDICINE, vol. 48, no. 3, March 2007 (2007-03-01), pages 420 - 428, XP002578050, ISSN: 0161-5505
SHOLTZ K F ET AL: "Probing the active center of the mitochondrial dicarboxylate transporter", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/0014-5793(93)81038-2, vol. 327, no. 1, 19 July 1993 (1993-07-19), pages 54 - 56, XP025605807, ISSN: 0014-5793, [retrieved on 19930719]
YOSHIMOTO M ET AL: "Characterization of acetate metabolism in tumor cells in relation to cell proliferation: Acetate metabolism in tumor cells", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY, US LNKD- DOI:10.1016/S0969-8051(00)00195-5, vol. 28, no. 2, 1 February 2001 (2001-02-01), pages 117 - 122, XP004233295, ISSN: 0969-8051
PONDE DATTA E ET AL: "F-18-fluoroacetate: A potential acetate analog for prostate tumor imaging - In vivo evaluation of F-18-fluoroacetate versus C-11-acetate", JOURNAL OF NUCLEAR MEDICINE, vol. 48, no. 3, March 2007 (2007-03-01), pages 420 - 428, XP002578050, ISSN: 0161-5505
SHOLTZ K F ET AL: "Probing the active center of the mitochondrial dicarboxylate transporter", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/0014-5793(93)81038-2, vol. 327, no. 1, 19 July 1993 (1993-07-19), pages 54 - 56, XP025605807, ISSN: 0014-5793, [retrieved on 19930719]
Attorney, Agent or Firm:
POMPER, Till (Kurig Strau, Bavariastrasse 7 München, DE)
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