Title:
PREDICTION OF RISK OF ONSET OF DRUG-INDUCED PULMONARY DISORDERS, AND METHOD AND KIT FOR DETECTION OF GENE FOR THE PREDICTION OF THE RISK
Document Type and Number:
WIPO Patent Application WO/2011/155531
Kind Code:
A1
Abstract:
Disclosed are: a method for detecting the presence or absence of a single nucleotide polymorphism of a gene for the purpose of predicting the risk of onset of drug-induced pulmonary disorders or improving a therapeutic method for drug-induced pulmonary disorders; and a kit for achieving the method. The method is characterized by comparing an ABCB1 gene in a biological sample with a wild-type ABCB1 gene to detect the presence or absence of a single nucleotide polymorphism in the ABCB1 gene in the biological sample, particularly determining the nucleotide at position-3751 in a CDS in ABCB1 gene. The kit comprises an oligonucleotide probe capable of binding specifically to a single nucleotide polymorphism of ABCB1 gene under selective binding conditions or an oligonucleotide primer capable of amplifying a nucleic acid sequence that contains a single nucleotide polymorphism of ABCB1 gene.
Inventors:
KOIZUMI FUMIAKI (JP)
KANDA SHINTARO (JP)
TAMURA TOMOHIDE (JP)
GOTO KOICHI (JP)
SEKIJIMA MASARU (JP)
OHIDE AKIRA (JP)
NISHIO KAZUTO (JP)
KANDA SHINTARO (JP)
TAMURA TOMOHIDE (JP)
GOTO KOICHI (JP)
SEKIJIMA MASARU (JP)
OHIDE AKIRA (JP)
NISHIO KAZUTO (JP)
Application Number:
PCT/JP2011/063142
Publication Date:
December 15, 2011
Filing Date:
June 08, 2011
Export Citation:
Assignee:
NAT CANCER CT (JP)
MITSUBISHI CHEM MEDIENCE CORP (JP)
UNIV KINKI (JP)
KOIZUMI FUMIAKI (JP)
KANDA SHINTARO (JP)
TAMURA TOMOHIDE (JP)
GOTO KOICHI (JP)
SEKIJIMA MASARU (JP)
OHIDE AKIRA (JP)
NISHIO KAZUTO (JP)
MITSUBISHI CHEM MEDIENCE CORP (JP)
UNIV KINKI (JP)
KOIZUMI FUMIAKI (JP)
KANDA SHINTARO (JP)
TAMURA TOMOHIDE (JP)
GOTO KOICHI (JP)
SEKIJIMA MASARU (JP)
OHIDE AKIRA (JP)
NISHIO KAZUTO (JP)
International Classes:
C12Q1/68; C12N15/09; G01N33/53
Other References:
CHEN C J ET AL.: "Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.", J BIOL CHEM., vol. 265, no. 1, 1990, pages 506 - 514
ISHIKAWA T ET AL.: "Pharmacogenomics of drug transporters - From basic research to clinical applications.", IGAKU NO AYUMI., vol. 230, no. 6-7, 2009, pages 447 - 452
ISHIKAWA T ET AL.: "Pharmacogenomics of drug transporters - From basic research to clinical applications.", IGAKU NO AYUMI., vol. 230, no. 6-7, 2009, pages 447 - 452
Attorney, Agent or Firm:
MORITA Kenichi et al. (JP)
Ken-ichi Morita (JP)
Ken-ichi Morita (JP)
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Claims:
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