PREDICTIVE DIAGNOSTIC MARKER FOR ALZHEIMER'S DISEASE USING DNA METHYLATION CHANGE IN KRT32 GENE

WIPO Patent Application WO/2024/019556

A1

The present invention relates to a composition, kit, and method for predicting the risk of progression of Alzheimer's disease by detecting the methylation level of the CpG region of a Keratin 32 (KRT32) gene promoter, and has the effect of representing clinical symptoms for early diagnosis of Alzheimer's disease or measuring preclinical conditions before symptoms appear.

AHN JUNG-HYUCK (KR)
LEE HYUNJU (KR)
JEONG JEE HYANG (KR)
PARK HEE KYUNG (KR)
SUNG HYE YOUN (KR)

PCT/KR2023/010461

January 25, 2024

July 20, 2023

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UNIV EWHA IND COLLABORATION (KR)
GWANGJU INST SCIENCE & TECH (KR)

C12Q1/6883

KR20210109213A	2021-09-06
KR101718940B1	2017-03-22
US20200080132A1	2020-03-12

JING QI, ZHANG HUI, SUN XIAORU, XU YARU, CAO SILU, FANG YILING, ZHAO XUAN, LI CHENG: "A Comprehensive Analysis Identified Hub Genes and Associated Drugs in Alzheimer’s Disease", BIOMED RESEARCH INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, vol. 2021, 9 January 2021 (2021-01-09), pages 1 - 10, XP093131968, ISSN: 2314-6133, DOI: 10.1155/2021/8893553
RICHENS JOANNA L., SPENCER HANNAH L., BUTLER MOLLY, CANTLAY FIONA, VERE KELLY-ANN, BAJAJ NIN, MORGAN KEVIN, O’SHEA PAUL: "Rationalising the role of Keratin 9 as a biomarker for Alzheimer’s disease", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 6, no. 1, US , XP093131971, ISSN: 2045-2322, DOI: 10.1038/srep22962

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