Title:
PREDICTIVE RESPONSE BIOMARKER DISCOVERY PROCESS
Document Type and Number:
WIPO Patent Application WO/2023/187468
Kind Code:
A3
Abstract:
The invention described herein provides a method to identify predictive response biomarkers (PRBs) for a treatment regimen. The PRBs can be used to identify suitable or unsuitable) patient population for the treatment regimen.
Inventors:
SCHWEIZER LIANG (US)
RAUE ANDREAS (US)
LEE DEAN SUNG-LING (US)
RAUE ANDREAS (US)
LEE DEAN SUNG-LING (US)
Application Number:
PCT/IB2023/000166
Publication Date:
December 14, 2023
Filing Date:
March 27, 2023
Export Citation:
Assignee:
HIFIBIO HK LTD (CN)
International Classes:
C12N5/00; C12N5/0783; C12Q1/6881; C12Q1/6886; G01N33/50
Domestic Patent References:
| WO2021257890A1 | 2021-12-23 |
Other References:
LEE DEAN ET AL: "Abstract PO-048: Combined single-T cell clonotyping and phenotyping defines a predictive response signature that identifies patients more likely to respond to therapy", CANCER RESEARCH, vol. 80, no. 21_Supplement, 1 November 2020 (2020-11-01), US, pages PO - 048, XP093079700, ISSN: 0008-5472, Retrieved from the Internet DOI: 10.1158/1538-7445.TUMHET2020-PO-048
WEI S ET AL: "Abstract 1883: Mechanism of action and biomarker strategy for HFB200301, an anti-TNFR2 agonist antibody for the treatment of cancer", CANCER RESEARCH; AACR ANNUAL MEETING 2021, 20210517 TO 20210521, PHILADELPHIA, PA, USA, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 81, no. 13 SUPPL, 1 July 2021 (2021-07-01), pages 1883, XP009547496, ISSN: 1538-7445, DOI: 10.1158/1538-7445.AM2021-1883
LEE DEAN ET AL: "Single-cell immune profiling with TCR clonotype barcoding identifies biomarker signatures that predict response to immune checkpoint blockade", BIORXIV, 14 April 2021 (2021-04-14), XP093079698, Retrieved from the Internet [retrieved on 20230907], DOI: 10.1101/2021.04.13.439713
WEI S ET AL: "Abstract 1883: Mechanism of action and biomarker strategy for HFB200301, an anti-TNFR2 agonist antibody for the treatment of cancer", CANCER RESEARCH; AACR ANNUAL MEETING 2021, 20210517 TO 20210521, PHILADELPHIA, PA, USA, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 81, no. 13 SUPPL, 1 July 2021 (2021-07-01), pages 1883, XP009547496, ISSN: 1538-7445, DOI: 10.1158/1538-7445.AM2021-1883
LEE DEAN ET AL: "Single-cell immune profiling with TCR clonotype barcoding identifies biomarker signatures that predict response to immune checkpoint blockade", BIORXIV, 14 April 2021 (2021-04-14), XP093079698, Retrieved from the Internet
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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