Title:
PRENYL FLAVONOIDS,THEIR PREPARATION AND USE
Document Type and Number:
WIPO Patent Application WO/2008/014722
Kind Code:
A1
Abstract:
Prenyl flavonoids, their preparation and use. The prenyl flavonoids are shown by
formula I,in which ring A is five or six carbon ring glucide, or disaccharide; R
is substitute of hydroxy on ring A selected from H,COCmH2m+1(m is
natural number from 1 to 6) and CmH2m+1(m is natural number from
1 to 6); n is natural number from 1 to 7; R1 is selected from H,C1-C6alkyl,C3-C8cycloalkyl,C2-C6alkenyl,C2-C6acyl or
C7-C12aroyl;R2 and R3 are selected from
H or C1-C6alkyl.The invention also provides a process for
preparing the compounds above. The invention further provides a drug including the
compounds above and their medicinal acceptable salt. The drug is used to cure or
prevent such diseases relevant to cGMP-PDE V.
Inventors:
SHEN JINGSHAN (CN)
ZHANG SHUJUN (CN)
GUO HONGLI (CN)
CHEN XINJIAN (CN)
NIAN YIFENG (CN)
ZHANG SHUJUN (CN)
GUO HONGLI (CN)
CHEN XINJIAN (CN)
NIAN YIFENG (CN)
Application Number:
PCT/CN2007/070375
Publication Date:
February 07, 2008
Filing Date:
July 27, 2007
Export Citation:
Assignee:
TOPHARMAN SHANGHAI CO LTD (CN)
SHANGHAI INST MATERIA MEDICA (CN)
UNIV QIQIHAR (CN)
SHEN JINGSHAN (CN)
ZHANG SHUJUN (CN)
GUO HONGLI (CN)
CHEN XINJIAN (CN)
NIAN YIFENG (CN)
SHANGHAI INST MATERIA MEDICA (CN)
UNIV QIQIHAR (CN)
SHEN JINGSHAN (CN)
ZHANG SHUJUN (CN)
GUO HONGLI (CN)
CHEN XINJIAN (CN)
NIAN YIFENG (CN)
International Classes:
C07H17/07; A61K31/352; A61K31/7048; A61P15/10; C07D311/30
Foreign References:
| US6399579B1 | 2002-06-04 | |||
| CN1473938A | 2004-02-11 | |||
| CN1684950A | 2005-10-19 | |||
| CN1093086A | 1994-10-05 |
Other References:
LI W.K. ET AL.: "The Spectroscopic Characteristics of 8-Prenyl Flavanoids", HUAXI YAOXUE ZAZHI, vol. 11, no. 1, 1996, pages 1 - 4
HAIRUI LIANG ET AL.: "New Flavonol Glycoside From Epimedium Acuminatum", J. NAT. PROD., vol. 56, no. 6, 1993, pages 943 - 945
CHIU C.-Y. ET AL.: "Constituents of Leaves of Phellodendron japonicum MAXIM, and Their Antioxidant Activity", CHEM. PHARM. BULL., vol. 53, no. 9, 2005, pages 1118 - 1121
HAIRUI LIANG ET AL.: "New Flavonol Glycoside From Epimedium Acuminatum", J. NAT. PROD., vol. 56, no. 6, 1993, pages 943 - 945
CHIU C.-Y. ET AL.: "Constituents of Leaves of Phellodendron japonicum MAXIM, and Their Antioxidant Activity", CHEM. PHARM. BULL., vol. 53, no. 9, 2005, pages 1118 - 1121
Attorney, Agent or Firm:
BEIJING HUIZE INTELLECTUAL PROPERTY LAW LLC (A18 Horizon International Tower,No.6, Zhichun Road,Haidian District, Beijing 8, CN)
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