Title:
PREPARATION OF AMPHETAMINES FROM PHENYLPROPANOLAMINES
Document Type and Number:
WIPO Patent Application WO2003037843
Kind Code:
A3
Abstract:
A process for making an amphetamine from a phenylpropanolamine salt, the process comprising: (a) acylating the phenylpropanolamine salt with an acylating agent in a solvent at elevated temperature to make a reaction mixture containing an O-acylated phenylpropanolamine salt which can be isolated by the addition of a crystallization solvent, or optionally this mixture can be used in the next step; and (b) hydrogenating the O-acylated phenylpropanolamine salt to make the amphetamine in thepresence of a catalyst.
Inventors:
BOSWELL ROBERT FREDERICK
LO YOUNG SEK
LO YOUNG SEK
Application Number:
PCT/US2002/034400
Publication Date:
October 30, 2003
Filing Date:
October 28, 2002
Export Citation:
Assignee:
BOEHRINGER INGELHEIM CHEMICALS (US)
International Classes:
C07B61/00; C07C209/68; C07C211/27; (IPC1-7): C07C209/68; C07C213/06
Foreign References:
| US2802828A | 1957-08-13 | |||
| FR2389597A1 | 1978-12-01 |
Other References:
HANS-G. BOIT: "Beilsteins Handbuch der Organischen Chemie, vol. XIII, 4th Ed., Third Suppl., pages 1718, 1719, 1724, 1725", 1973, SPRINGER VERLAG, BERLIN . HEIDELBERG . NEW YORK, XP002235851
REINER LUCKENBACH: "Beilstein Handbuch der Organischen Chemie, vol. XII, 4th Ed., 4th Suppl., p. 2586 to 2591", 1984, SPRINGER VERLAG, BERLIN . HEIDELBERG . NEW YORK TOKYO, XP002235852
HANS-G. BOIT: "Beilsteins Handbuch der Organischen Chemie, vol. XII, 4th Ed., Third Suppl. page 2664 to page 2669", 1973, SPRINGER VERLAG, BERLIN . HEIDELBERG . NEW YORK, XP002235853
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002235854
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002235855
LLEWELLYN H. WELSH: "The constitution of Acetylephedrine and acetyl-psi-ephedrine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 69, 1947, DC US, pages 128 - 136, XP002244101
HANS-G. BOIT: "Beilsteins Handbuch der organischen Chemie, vol. XIII, 4th Edition, 3th Suppl., pages 1724-1725", 1973, SPRINGER-VERLAG, BERLIN . HEIDELBERG . NEW YORK, XP002244102
REINER LUCKENBACH: "Beilstein Handbuch der Organischen Chemie, vol. XII, 4th Ed., 4th Suppl., p. 2586 to 2591", 1984, SPRINGER VERLAG, BERLIN . HEIDELBERG . NEW YORK TOKYO, XP002235852
HANS-G. BOIT: "Beilsteins Handbuch der Organischen Chemie, vol. XII, 4th Ed., Third Suppl. page 2664 to page 2669", 1973, SPRINGER VERLAG, BERLIN . HEIDELBERG . NEW YORK, XP002235853
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002235854
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002235855
LLEWELLYN H. WELSH: "The constitution of Acetylephedrine and acetyl-psi-ephedrine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 69, 1947, DC US, pages 128 - 136, XP002244101
HANS-G. BOIT: "Beilsteins Handbuch der organischen Chemie, vol. XIII, 4th Edition, 3th Suppl., pages 1724-1725", 1973, SPRINGER-VERLAG, BERLIN . HEIDELBERG . NEW YORK, XP002244102
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