PREPARATION AND APPLICATIONS OF CHIMERIC ANTIGEN RECEPTOR T-CELL CO-EXPRESSING IMMUNOMODULATORY MOLECULE

Title:

PREPARATION AND APPLICATIONS OF CHIMERIC ANTIGEN RECEPTOR T-CELL CO-EXPRESSING IMMUNOMODULATORY MOLECULE

Document Type and Number:

WIPO Patent Application WO/2021/136040

Kind Code:

A1

Abstract:

Provided in the present invention are a preparation and applications of a chimeric antigen receptor T-cell co-expressing an immunomodulatory molecule. Specifically, provided in the present invention are a CAR and the CAR-T-cell thereof specifically targeting a tumor cell surface antigen, the chimeric antigen receptor (CAR) comprises an antigen-binding structural domain and an immunomodulatory molecule. The CAR-T-cell of the present invention provides excellent tumor-killing effects.

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Inventors:

TAN BINGHE (CN)
SHI XIUJUAN (CN)
DU BING (CN)
LIU MINGYAO (CN)
XI ZAIXI (CN)

Application Number:

PCT/CN2020/138691

Publication Date:

July 08, 2021

Filing Date:

December 23, 2020

Export Citation:

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Assignee:

UNIV EAST CHINA NORMAL (CN)
BIORAY LABORATORIES INC (CN)

International Classes:

C07K19/00; A61K35/00; A61K48/00; C12N15/09

Foreign References:

CN106467906A

2017-03-01

Attorney, Agent or Firm:

XU & PARTNERS, LLC. (CN)

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