Title:
PREPARATION COMPRISING HEXOSE-6-PHOSPHATE-MODIFIED CHOLESTEROL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2013/035757
Kind Code:
A1
Abstract:
The present invention provides a compound represented by general formula (1). In general formula (1): G represents a hexose-6-phosphate group; and L represents a divalent linker group.
Inventors:
UN KEITA (JP)
HASHIDA MITSURU (JP)
KAWAKAMI SHIGERU (JP)
KISO MAKOTO (JP)
UEKI AKIHARU (JP)
ANDO HIROMUNE (JP)
HASHIDA MITSURU (JP)
KAWAKAMI SHIGERU (JP)
KISO MAKOTO (JP)
UEKI AKIHARU (JP)
ANDO HIROMUNE (JP)
Application Number:
PCT/JP2012/072651
Publication Date:
March 14, 2013
Filing Date:
September 05, 2012
Export Citation:
Assignee:
UNIV KYOTO (JP)
UNIV GIFU (JP)
UN KEITA (JP)
HASHIDA MITSURU (JP)
KAWAKAMI SHIGERU (JP)
KISO MAKOTO (JP)
UEKI AKIHARU (JP)
ANDO HIROMUNE (JP)
UNIV GIFU (JP)
UN KEITA (JP)
HASHIDA MITSURU (JP)
KAWAKAMI SHIGERU (JP)
KISO MAKOTO (JP)
UEKI AKIHARU (JP)
ANDO HIROMUNE (JP)
International Classes:
C07J9/00; A61K9/127; A61K31/704; A61K31/7088; A61K31/7105; A61K31/711; A61K45/00; A61K47/28; A61K48/00; A61P1/16; A61P3/00; A61P3/10; A61P35/00; C12N15/09; C12N15/113; C12N15/115
Domestic Patent References:
| WO2005011632A1 | 2005-02-10 | |||
| WO2007089043A1 | 2007-08-09 |
Foreign References:
| JP2007112768A | 2007-05-10 |
Other References:
PRAKASH J ET AL.: "Tumor-targeted intracellular delivery of anticancer drugs through the mannose-6-phosphate/insulin-like growth factor II receptor", INT. J. CANCER, vol. 126, 2010, pages 1966 - 1981
GREUPINK R ET AL.: "The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo", J. PHARMACOL. EXP. THER., vol. 317, 2006, pages 514 - 521
AKIHARU UEKI ET AL.: "DDS o Shiko shita To Shushoku Cholesterol no Gosei to To Shushoku Liposome no Kino Hyoka", DAI 31 KAI THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAI YOSHISHU, 31 August 2012 (2012-08-31), pages 163
GREUPINK R ET AL.: "The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo", J. PHARMACOL. EXP. THER., vol. 317, 2006, pages 514 - 521
AKIHARU UEKI ET AL.: "DDS o Shiko shita To Shushoku Cholesterol no Gosei to To Shushoku Liposome no Kino Hyoka", DAI 31 KAI THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAI YOSHISHU, 31 August 2012 (2012-08-31), pages 163
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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