PREPARATION OF D-(-) -1-SUBSTITUTED PHENYL-2-DICHLORO-ACETOAMINO-3FLUORO-1-PROPANOL FROM L TYPE SUBSTITUTED PHENYL SERINE ESTER

WIPO Patent Application WO/2003/093221

A1

This invention relates to the preparation of D-(-)-substituted phenyl-2-dichloroacetoamino-3-fluoro-1-propanol, the method involves using L type substituted phenyl serine ester extracted and purified from resolution waste liquid as raw material and through stepped reactions. The process is simple, high yielded, low costed and complete in configuration and is an effective and simple method of converting L type substituted phenyl serine ester to D type fluorothiamphenicol. The invention can prevent from disposing waste antimer produced in the resolution process of producing Florfenicol, reduce environmental pollution and has certain practical significance.

LIN GUOQIANG (CN)
LEI XINSHENG (CN)
HUANG HAO (CN)
YU XIAOMING (CN)
LI RONG (CN)

PCT/CN2002/000354

November 13, 2003

May 27, 2002

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SHANGHAI INST ORGANIC CHEM (CN)
LIN GUOQIANG (CN)
LEI XINSHENG (CN)
HUANG HAO (CN)
YU XIAOMING (CN)
LI RONG (CN)

C07C231/10; C07C233/18; C07C255/58; C07C317/32; (IPC1-7): C07C233/18; C07C255/58; C07C317/32

CN1233244A

1999-10-27

DATABASE CA [online] KAPTEIN B. ET AL.: "Synthesis of 4-sulfur-substituted (2S,3R)-3-phenylserines by enzymic resolution. Enantiopure precursors for thiamphenicol and florfenicol", accession no. STN Database accession no. 128:23109
DATABASE CA [online] CLARK JON E. ET AL.: "An enzymic route to florfenicol", accession no. STN Database accession no. 116:128730

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