Title:
PREPARATION METHOD OF (5-FLUORO-2, 3-DIHYDROBENZOFURAN-4-YL) METHANAMINE OR ITS SALT, AND INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/228034
Kind Code:
A1
Abstract:
Provided is a preparation method of (5-fluoro-2, 3-dihydrobenzofuran-4-yl) methylamine or a salt thereof, which uses 4-fluoro-3-methylphenol as the starting material, and is carried out through the steps of bromination, O-alkylation, cyclization, bromination, azidation or ammonolysis, and reduction. The reaction route has simple synthesis process, convenient operation, high yield, and is environmentally friendly. The prepared (5-fluoro-2, 3-dihydrobenzofuran-4-yl) methylamine can be used as an intermediate in pharmaceuticals and fine chemicals.
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Inventors:
WU QINGQUAN (CN)
WANG XIULING (CN)
WANG JIAWEI (CN)
ZHOU RUBIN (CN)
WANG XIULING (CN)
WANG JIAWEI (CN)
ZHOU RUBIN (CN)
Application Number:
PCT/CN2021/092728
Publication Date:
November 18, 2021
Filing Date:
May 10, 2021
Export Citation:
Assignee:
ASCENTAGE PHARMA SUZHOU CO LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
International Classes:
C07D307/78; C01B9/04; C07C39/04; C07C39/06
Domestic Patent References:
| WO2019158025A1 | 2019-08-22 | |||
| WO2016103155A1 | 2016-06-30 | |||
| WO2017221100A1 | 2017-12-28 | |||
| WO2019120276A1 | 2019-06-27 |
Foreign References:
| CN110563722A | 2019-12-13 | |||
| CN110734436A | 2020-01-31 |
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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