Title:
PREPARATION METHOD FOR ACESULFAME POTASSIUM
Document Type and Number:
WIPO Patent Application WO/2022/246865
Kind Code:
A1
Abstract:
Provided is a preparation method for acesulfame potassium, which comprises: a pretreatment step, involving: treating an acetoacetamide-N-sulfonic acid triethylamine salt solution with a weakly alkaline inorganic substance to obtain an intermediate solution; a sulfonation cyclization step, involving: dissolving sulfur trioxide in a solvent to form a cyclizing agent solution, and subjecting the intermediate solution and the cyclizing agent solution to a sulfonation cyclization reaction so as to obtain a sulfonation cyclization product; a hydrolysis step, involving: adding a hydrolysis agent to a solution of the sulfonation cyclization product, and carrying out a hydrolysis reaction to obtain a hydrolysate solution; and a salt-forming step, involving: adding a salt-forming agent to an organic phase of the hydrolysate solution, and carrying out a salt-forming reaction to obtain acesulfame potassium. According to the method, on the one hand, an acid catalyst remaining in the final product acesulfame potassium is removed; on the other hand, the reaction environment provided by the weakly alkaline inorganic substance inhibits the generation of by-products and increases the purity of the acesulfame potassium product; and the yield of the acesulfame potassium can be significantly increased, and the production cost of the acesulfame potassium is lowered.
Inventors:
ZHOU RUI (CN)
DING ZHEN (CN)
CHEN YONGXU (CN)
YANG FENGBAO (CN)
LIU GANG (CN)
DING ZHEN (CN)
CHEN YONGXU (CN)
YANG FENGBAO (CN)
LIU GANG (CN)
Application Number:
PCT/CN2021/097013
Publication Date:
December 01, 2022
Filing Date:
May 28, 2021
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07D291/06
Foreign References:
| CN104411693A | 2015-03-11 | |||
| CN111377882A | 2020-07-07 |
Other References:
X. DUAN ET AL.: "Synthesis of Acesulfame Potassium", FINE CHEMICALS, vol. 13, no. 5, 1 January 1996 (1996-01-01), pages 22 - 24, XP055436957, ISSN: 1003-5214, DOI: 10.13550/j .jxhg.1996.05.007
"Inorganic and Analytical Chemistry Experiments", 28 February 2007, HIGHER EDUCATION PRESS, CN, ISBN: 978-7-04-020551-0, article NI, JINGAN ET AL: "Experiment 89: Preparation and Characterization of Solid Superacid", pages: 1 - 3, XP009543004
MA QIANLI; SUO YANHUA; MENG FANLONG; ZHANG WEI; WANG YINGJUN: "Research Advance in Modification and Application of SO42-/MxOy Solid Superacid Catalyst", INDUSTRIAL CATALYSIS, vol. 22, no. 2, 31 December 1996 (1996-12-31), China , pages 85 - 91, XP009541276, ISSN: 1008-1143, DOI: 10.3969/j.issn.1008-1143.2014.02.002
"Inorganic and Analytical Chemistry Experiments", 28 February 2007, HIGHER EDUCATION PRESS, CN, ISBN: 978-7-04-020551-0, article NI, JINGAN ET AL: "Experiment 89: Preparation and Characterization of Solid Superacid", pages: 1 - 3, XP009543004
MA QIANLI; SUO YANHUA; MENG FANLONG; ZHANG WEI; WANG YINGJUN: "Research Advance in Modification and Application of SO42-/MxOy Solid Superacid Catalyst", INDUSTRIAL CATALYSIS, vol. 22, no. 2, 31 December 1996 (1996-12-31), China , pages 85 - 91, XP009541276, ISSN: 1008-1143, DOI: 10.3969/j.issn.1008-1143.2014.02.002
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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