Title:
PREPARATION METHOD FOR ACESULFAME POTASSIUM
Document Type and Number:
WIPO Patent Application WO/2022/246868
Kind Code:
A1
Abstract:
Provided is a preparation method for acesulfame potassium, comprising: a salt-forming step: separating a sulfonation cyclization product solution into an organic phase and an inorganic phase, and adding an ethanolic solution of potassium ethoxide to the organic phase to carry out a salt-forming reaction, wherein the sulfonation cyclization product solution is obtained by hydrolysis of the product of cycloaddition of acetoacetamide-N-sulfonic acid triethylamine salt and sulfur trioxide; and a washing step: after the salt-forming reaction is completed, filtering to obtain a solid product, and washing the solid product with ethanol to obtain a crude product of acesulfame potassium. The method greatly reduces the content of inorganic impurities in the crude product of acesulfame potassium, thereby significantly improving the purity of a final product, i.e., acesulfame potassium, simplifies the subsequent process for the crude product of acesulfame potassium, reduces the costs of purification of the crude product of acesulfame potassium, and can improve the yield of acesulfame potassium.
Inventors:
ZHOU RUI (CN)
DING ZHEN (CN)
CHEN YONGXU (CN)
YANG FENGBAO (CN)
LIU GANG (CN)
DING ZHEN (CN)
CHEN YONGXU (CN)
YANG FENGBAO (CN)
LIU GANG (CN)
Application Number:
PCT/CN2021/097016
Publication Date:
December 01, 2022
Filing Date:
May 28, 2021
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07D291/06
Foreign References:
| CN104411693A | 2015-03-11 | |||
| CN111377882A | 2020-07-07 |
Other References:
X. DUAN ET AL.: "Synthesis of Acesulfame Potassium", FINE CHEMICALS, vol. 13, no. 5, 1 January 1996 (1996-01-01), pages 22 - 24, XP055436957, ISSN: 1003-5214, DOI: 10.13550/j .jxhg.1996.05.007
"Inorganic and Analytical Chemistry Experiments", 28 February 2007, HIGHER EDUCATION PRESS, CN, ISBN: 978-7-04-020551-0, article NI, JINGAN ET AL.: "Experiment 89: Preparation and Characterization of Solid Superacid", pages: 1 - 3, XP009543004
MA QIANLI; SUO YANHUA; MENG FANLONG; ZHANG WEI; WANG YINGJUN: "Research Advance in Modification and Application of SO42-/MxOy Solid Superacid Catalyst", INDUSTRIAL CATALYSIS, NORTHWEST RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA, vol. 22, no. 2, 1 February 2014 (2014-02-01), China , pages 85 - 91, XP009541276, ISSN: 1008-1143, DOI: 10.3969/j.issn.1008-1143.2014.02.002
"Inorganic and Analytical Chemistry Experiments", 28 February 2007, HIGHER EDUCATION PRESS, CN, ISBN: 978-7-04-020551-0, article NI, JINGAN ET AL.: "Experiment 89: Preparation and Characterization of Solid Superacid", pages: 1 - 3, XP009543004
MA QIANLI; SUO YANHUA; MENG FANLONG; ZHANG WEI; WANG YINGJUN: "Research Advance in Modification and Application of SO42-/MxOy Solid Superacid Catalyst", INDUSTRIAL CATALYSIS, NORTHWEST RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA, vol. 22, no. 2, 1 February 2014 (2014-02-01), China , pages 85 - 91, XP009541276, ISSN: 1008-1143, DOI: 10.3969/j.issn.1008-1143.2014.02.002
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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