PREPARATION METHOD FOR AMIDE COMPOUND AND APPLICATION THEREOF IN FIELD OF MEDICINE

WIPO Patent Application WO/2020/192650

A1

The present invention relates to a preparation method for an amide compound and an application thereof in the field of medicine. Specifically, provided by the present invention is an amide small molecule compound which is an inhibitor of Zeste gene enhancer homolog 2 (EZH2) and which may be used to prevent and/or treat EZH2-mediated related diseases, comprising tumors, myeloproliferative diseases or autoimmune diseases.

JP2002534415	[Title of Invention] New Compound
JPS5538356	INSECTICIDE
JPH08506329	INDUSTRIAL APPLICABILITY [Title of Invention] Substituted tetrahydropyridazinecarboxamides

XU XIN (CN)
ZHANG ZHEN (CN)
LI YUNFEI (CN)
ZHANG LIMING (CN)
WU QIMEI (CN)
XIA XIAOER (CN)
JIANG QINGYUN (CN)
WANG LONGGANG (CN)
YANG MAOZHI (CN)
LIU LEI (CN)
XU YANXIAO (CN)
ZHOU XIAOBO (CN)
YANG XUQIN (CN)
ZHANG XIAOJUAN (CN)
WANG YIJIN (CN)
GE JIAN (CN)

PCT/CN2020/080870

October 01, 2020

March 24, 2020

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SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO LTD (CN)
ZHEJIANG HUAHAI PHARM CO LTD (CN)

C07D213/64; A61K31/4412; A61K31/4433; A61K31/444; A61P35/00; A61P35/02; C07D401/12; C07D401/14; C07D405/12

WO2018137639A1	2018-08-02
WO2012005805A1	2012-01-12
WO2012050532A1	2012-04-19
WO2012118812A2	2012-09-07
WO2015143424A2	2015-09-24
WO2016102493A1	2016-06-30
WO2017084494A1	2017-05-26
WO2018045971A1	2018-03-15

CN104080769A	2014-10-01
CN108314677A	2018-07-24
CN105307683A	2016-02-03
CN201910228244A	2019-03-25
CN201910687575A	2019-07-29

See also references of EP 3950676A4

PATENTSINO IP FIRM (CN)

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