Title:
PREPARATION METHOD FOR AMIDE COMPOUNDS AND USE THEREOF IN MEDICAL FIELD
Document Type and Number:
WIPO Patent Application WO/2020/192652
Kind Code:
A1
Abstract:
Provided are a preparation method for amide compounds and use thereof in medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer homolog 2 (EZH2) of Zeste gene, and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases, or autoimmune diseases.
Inventors:
LI YUNFEI (CN)
XU XIN (CN)
ZHANG ZHEN (CN)
ZHANG LIMING (CN)
WU QIMEI (CN)
XIA XIAOER (CN)
JIANG QINGYUN (CN)
WANG LONGGANG (CN)
GUO FENGYING (CN)
YU HAO (CN)
ZHOU XIAOBO (CN)
LIU LEI (CN)
ZHANG XIAOJUAN (CN)
WANG YIJIN (CN)
GE JIAN (CN)
XU XIN (CN)
ZHANG ZHEN (CN)
ZHANG LIMING (CN)
WU QIMEI (CN)
XIA XIAOER (CN)
JIANG QINGYUN (CN)
WANG LONGGANG (CN)
GUO FENGYING (CN)
YU HAO (CN)
ZHOU XIAOBO (CN)
LIU LEI (CN)
ZHANG XIAOJUAN (CN)
WANG YIJIN (CN)
GE JIAN (CN)
Application Number:
PCT/CN2020/080874
Publication Date:
October 01, 2020
Filing Date:
March 24, 2020
Export Citation:
Assignee:
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO LTD (CN)
ZHEJIANG HUAHAI PHARM CO LTD (CN)
ZHEJIANG HUAHAI PHARM CO LTD (CN)
International Classes:
C07D401/12; A61K31/4412; A61K31/444; A61K31/5377; A61P35/00; C07D405/12; C07D413/12; C07D491/02; C07D491/10
Domestic Patent References:
| WO2017139404A1 | 2017-08-17 | |||
| WO2014172044A1 | 2014-10-23 | |||
| WO2013173441A2 | 2013-11-21 | |||
| WO2015010049A1 | 2015-01-22 | |||
| WO2015110999A1 | 2015-07-30 | |||
| WO2012005805A1 | 2012-01-12 | |||
| WO2012050532A1 | 2012-04-19 | |||
| WO2012118812A2 | 2012-09-07 | |||
| WO2015143424A2 | 2015-09-24 | |||
| WO2016102493A1 | 2016-06-30 | |||
| WO2017084494A1 | 2017-05-26 | |||
| WO2018045971A1 | 2018-03-15 | |||
| WO2009124692A1 | 2009-10-15 |
Foreign References:
| CN104080769A | 2014-10-01 | |||
| US20170217941A1 | 2017-08-03 | |||
| CN201910228244A | 2019-03-25 | |||
| CN201910687575A | 2019-07-29 | |||
| EP2108641A1 | 2009-10-14 | |||
| US20120264734A1 | 2012-10-18 |
Other References:
J. MED. CHEM., vol. 59, 2016, pages 9928 - 9941
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, 2011, pages 5270 - 5273
See also references of EP 3950682A4
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, 2011, pages 5270 - 5273
See also references of EP 3950682A4
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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