Title:
PREPARATION METHOD FOR CHIRAL OXOAZACYCLOALKANE COMPOUND HAVING HIGH OPTICAL PURITY
Document Type and Number:
WIPO Patent Application WO/2021/147398
Kind Code:
A1
Abstract:
A preparation method for a chiral oxoazacycloalkane compound as shown in formula (I), comprising the steps of: using a compound as shown in formula (II) of R or S as a raw material, performing a cyclization reaction under the action of a solvent and a cyclization reagent, i.e. a Lewis acid-Lewis base, and then performing a thermal decarboxylation or a hydrolysis decarboxylation reaction. The raw material and product involved in the preparation method have a good chiral structure stability, and the target product has high optical purity and yield.
Inventors:
JIANG XIANLONG (CN)
ZHANG MINGFENG (CN)
QI YUXIN (CN)
ZHANG MINGFENG (CN)
QI YUXIN (CN)
Application Number:
PCT/CN2020/122111
Publication Date:
July 29, 2021
Filing Date:
October 20, 2020
Export Citation:
Assignee:
XIN FA PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D211/60; C07D207/16; C07D223/06
Foreign References:
| CN109970625A | 2019-07-05 | |||
| CN109970625A | 2019-07-05 | |||
| CN110452157A | 2019-11-15 | |||
| CN107540601A | 2018-01-05 | |||
| CN107540601A | 2018-01-05 | |||
| CN109400521A | 2019-03-01 | |||
| CN109400521A | 2019-03-01 | |||
| CN111072660A | 2020-04-28 | |||
| CN111072660A | 2020-04-28 |
Other References:
CHEN YIN; LAN YU; WANG SONGLIN; ZHANG HENG; XU XIANGQING; LIU XIN; YU MINQUAN; LIU BI-FENG; ZHANG GUISEN: "Synthesis and evaluation of new coumarin derivatives as potential atypical antipsychotics", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 74, 15 January 2014 (2014-01-15), AMSTERDAM, NL, pages 427 - 439, XP028623319, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.01.012
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JUNG, J.C. ; AVERY, M.A.: "Diastereoselective synthesis of (2S,5S)- and (2S,5R)-N-benzyloxycarbonyl-5-hydroxypipecolic acids from trans-4-hydroxy-l-proline", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 17, no. 17, 2 October 2006 (2006-10-02), OXFORD, GB, pages 2479 - 2486, XP024962414, ISSN: 0957-4166, DOI: 10.1016/j.tetasy.2006.07.035
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JUNG, J.C. ; AVERY, M.A.: "Diastereoselective synthesis of (2S,5S)- and (2S,5R)-N-benzyloxycarbonyl-5-hydroxypipecolic acids from trans-4-hydroxy-l-proline", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 17, no. 17, 2 October 2006 (2006-10-02), OXFORD, GB, pages 2479 - 2486, XP024962414, ISSN: 0957-4166, DOI: 10.1016/j.tetasy.2006.07.035
PEÇANHA EMERSON P, BARREIRO ELIEZER J, FRAGA CARLOS A M: "SÍNTESE DE β-CETOÉSTERES CÍCLICOS: NOVO PROCEDIMENTO PARA CICLIZAÇÕES DE DIECKMANN EMPREGANDO AlCl 3 E TRIETILAMINA SYNTHESIS OF b-KETO ESTERS: NEW EASY PROCEDURE FOR DIECKMANN CYCLIZA- TION EMPLOYING ALUMINUM CHLORIDE AND TRIETHYLAMINE", NOTA TÉCNICA, vol. 20, no. 4, 1 January 1997 (1997-01-01), pages 435 - 437, XP055830918
Attorney, Agent or Firm:
JINAN JINDI INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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