Title:
PREPARATION METHOD AND CONJUGATE WITH DRUG MOLECULE THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/052428
Kind Code:
A1
Abstract:
A class of polyethylene glycol-oligopeptide derivative is represented by the following general formula (I): (PEGi Xi )j A ( Fp)q (I), where: i, j, p and q are integers; i=1, 2,…, j; j≥=2; p=1, 2,…, q; q≥=1; PEGi is a polyethylene glycol chain; Xi is a linker group; A is a oligopeptide selected from Lys-Gly, Gly-Lys (Gly), Gly-Lys-Lys or Gly-Lys(Gly)-Lys; Fp is a active group. Their preparation methods and conjugates bonding medicine molecule by Fp are also provided. They may be useful for improving stability of medicine molecule in vivo or ensuring appropriate drug concentration and providing sustained-release function.
Inventors:
ZHAO XUAN (CN)
GU QIANG (CN)
GU QIANG (CN)
Application Number:
PCT/CN2007/003030
Publication Date:
May 08, 2008
Filing Date:
October 24, 2007
Export Citation:
Assignee:
BEIJING JENKEM TECHNOLOGY CO L (CN)
ZHAO XUAN (CN)
GU QIANG (CN)
ZHAO XUAN (CN)
GU QIANG (CN)
International Classes:
C07K5/02; C07K7/02; C07K17/08; C08G65/48
Foreign References:
| CN1706865A | 2005-12-14 | |||
| CN1556828A | 2004-12-22 | |||
| CN1442440A | 2003-09-17 | |||
| CN1626549A | 2005-06-15 | |||
| CN1461762A | 2003-12-17 | |||
| US5643575A | 1997-07-01 |
Attorney, Agent or Firm:
BEIJING ARETE INTELLECTUAL PROPERTY AGENCY (Building 3 Zhubang2000 Business Center,NO.98 Ba Li Zhuang Xi Li, Chaoyang District, Beijing 5, CN)
Download PDF: