Title:
PREPARATION METHOD FOR AND CRYSTAL FORM OF 3-ARYLOXY-3-FIVE-MEMBERED HETEROARYL-PROPYLAMINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/160134
Kind Code:
A1
Abstract:
Provided are a compound as represented by formula I, a preparation method therefor, and a hydrochloride crystal form A thereof. The compound as represented by formula I and the hydrochloride crystal form A thereof have excellent inhibitory effects on transient receptor potential (TRP) channels, and have good therapeutic effects on TRP channel-associated diseases.
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Inventors:
YU JUAN (CN)
WANG YOUXIN (CN)
YIN TINGTING (CN)
ZENG JINXIANG (CN)
ZHANG LINGLING (CN)
DING QIANG (CN)
WANG YOUXIN (CN)
YIN TINGTING (CN)
ZENG JINXIANG (CN)
ZHANG LINGLING (CN)
DING QIANG (CN)
Application Number:
PCT/CN2021/076337
Publication Date:
August 19, 2021
Filing Date:
February 09, 2021
Export Citation:
Assignee:
ZHANGZHOU PIEN TZE HUANG PHARM (CN)
SHANGHAI LEADO PHARMATECH CO LTD (CN)
SHANGHAI LEADO PHARMATECH CO LTD (CN)
International Classes:
C07D407/12; A61P11/00; A61P13/02; A61P29/00; C07D409/12
Domestic Patent References:
| WO2018115069A1 | 2018-06-28 | |||
| WO2018115064A1 | 2018-06-28 | |||
| WO2011128370A1 | 2011-10-20 | |||
| WO2020035070A1 | 2020-02-20 | |||
| WO2020035040A1 | 2020-02-20 | |||
| WO2010075353A1 | 2010-07-01 |
Foreign References:
| CN108947989A | 2018-12-07 | |||
| CN109748914A | 2019-05-14 | |||
| CN107840845A | 2018-03-27 |
Other References:
"Chinese Pharmacopoeia", 2015, article "Guidelines for Drug Hygroscopicity Test"
See also references of EP 4105212A4
See also references of EP 4105212A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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