Title:
PREPARATION METHOD FOR DECELLULARIZED MATRIX BIOMATERIAL
Document Type and Number:
WIPO Patent Application WO/2023/115912
Kind Code:
A1
Abstract:
The present application provides a preparation method for a decellularized matrix biomaterial, which combines specific pretreatment, degreasing, disinfection, decellularization, α-Gal antigen removal and sterilization, and reserves the integrity of bioactive components and structures in a material to the maximum extent while effectively removing an antigenic substance of an animal tissue, so that a decellularized matrix biomaterial having low immunogenicity and high biological activity is obtained. In addition, the decellularized matrix biomaterial prepared by the method provided by the present application effectively reduces immunogen components, has good biocompatibility and biological safety, is beneficial to cell adhesion, aggregation and proliferation on the surface, and can be used as a high-activity biological matrix material to be applied to skin soft tissue defect, gingival recession and periodontal soft tissue repair.
Inventors:
JIANG TAO (CN)
LI BO (CN)
RAN YONGFENG (CN)
YAN JIE (CN)
LI ZHIHONG (CN)
LI BO (CN)
RAN YONGFENG (CN)
YAN JIE (CN)
LI ZHIHONG (CN)
Application Number:
PCT/CN2022/105114
Publication Date:
June 29, 2023
Filing Date:
July 12, 2022
Export Citation:
Assignee:
HANGZHOU HUAMAI MEDICAL TECH CO LTD (CN)
International Classes:
A61L27/36; A61L27/58
Foreign References:
| CN114377206A | 2022-04-22 | |||
| CN107320777A | 2017-11-07 | |||
| CN110433341A | 2019-11-12 | |||
| CN110573188A | 2019-12-13 | |||
| CN104971380A | 2015-10-14 | |||
| CN112608380A | 2021-04-06 | |||
| US20200230291A1 | 2020-07-23 | |||
| CN101366975A | 2009-02-18 | |||
| CN110433341A | 2019-11-12 | |||
| CN106563173A | 2017-04-19 |
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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