Title:
PREPARATION METHOD FOR GRAFT-MODIFIED XANTHAN GUM NANO-SIZED MICROGEL
Document Type and Number:
WIPO Patent Application WO/2019/006881
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biomedical materials, especially to a preparation method for a graft-modified xanthan gum nano-sized microgel: firstly preparing N,N-bis(acryloyl)cystamine, and then carrying out graft polymerization and crosslinking reactions on xanthan gum with 2-acrylamido-2-methylpropane sulfonic acid and N,N-bis(acryloyl)cystamine, preparing and obtaining a graft-modified xanthan gum polymer, and forming a polymer nano-sized microgel in an aqueous solution. The graft polymerization of 2-acrylamido-2-methylpropane sulfonic acid onto xanthan gum can increase the drug-loading capability of the xanthan gum nano-sized microgel. The reductive sensitivity of the nano-sized microgel is imparted by the introduction of a disulfide bond. The nano-sized microgel of the present invention has a good biocompatibility and is degradable in vivo, and is anticipated to be used as an anti-cancer drug carrier and to be used in a controlled-release manner.
Inventors:
NI CAIHUA (CN)
XU JIE (CN)
ZHANG LIPING (CN)
SHI GANG (CN)
SANG XINXIN (CN)
XU JIE (CN)
ZHANG LIPING (CN)
SHI GANG (CN)
SANG XINXIN (CN)
Application Number:
PCT/CN2017/101897
Publication Date:
January 10, 2019
Filing Date:
September 15, 2017
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
C08F251/00; A61K31/704; A61K47/36; A61P35/00; C08F220/58; C08F222/38
Domestic Patent References:
| WO2004096127A2 | 2004-11-11 |
Foreign References:
| CN104974305A | 2015-10-14 | |||
| CN104224721A | 2014-12-24 | |||
| CN102492093A | 2012-06-13 |
Attorney, Agent or Firm:
WUXI SINO INTELLECTUAL PROPERTY AGENCY, LTD. (CN)
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