Title:
PREPARATION METHOD FOR HEPATITIS B VIRUS NUCLEOCAPSID INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/001298
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing a hepatitis B virus nucleocapsid inhibitor. Specifically, the method of the present invention obtains a novel method for preparing a compound represented by formula (I) (each group is as defined in the description) by an optimization process. The method can significantly enhance the yield, improve the product purity, and significantly reduce genotoxic impurities in the product. Also disclosed in the present invention is a new intermediate for the preparation of the compound represented by formula (I).
Inventors:
LIU GANG (CN)
LIANG BO (CN)
CHEN HUANMING (CN)
JIANG ZHAOJIAN (CN)
LIANG BO (CN)
CHEN HUANMING (CN)
JIANG ZHAOJIAN (CN)
Application Number:
PCT/CN2022/107463
Publication Date:
January 26, 2023
Filing Date:
July 22, 2022
Export Citation:
Assignee:
SHANGHAI ZHIMENG BIOPHARMA INC (CN)
International Classes:
C07D413/14; C07D413/04
Domestic Patent References:
| WO2017173999A1 | 2017-10-12 | |||
| WO2017173999A1 | 2017-10-12 |
Foreign References:
| CN109311865A | 2019-02-05 | |||
| US20170107234A1 | 2017-04-20 | |||
| CN106928098A | 2017-07-07 | |||
| CN102532042A | 2012-07-04 |
Other References:
BARBERO, N. ET AL.: "Copper-catalyzed intramolecular N-arylation of ureas in water: a novel entry to benzoimidazolones", TETRAHEDRON, vol. 64, 21 May 2008 (2008-05-21), pages 7283 - 7288, XP022762804, DOI: 10.1016/j.tet.2008.05.072
MCLAUGHLIN, M. ET AL.: "Efficient access to cyclic ureas via Pd-catalyzed cyclization", ORGANIC LETTERS, vol. 8, no. 15, 22 June 2006 (2006-06-22), pages 3311 - 3314, XP002452928, DOI: 10.1021/ol061233j
WILFRIED, H. ET AL.: "Synthesis of non glycosidic nucleobase-sugar mimetics", COMPTES RENDUS CHIMIE, vol. 13, no. 10, 8 February 2010 (2010-02-08), pages 1284 - 1300, XP027298825
MCLAUGHLIN, M. ET AL.: "Efficient access to cyclic ureas via Pd-catalyzed cyclization", ORGANIC LETTERS, vol. 8, no. 15, 22 June 2006 (2006-06-22), pages 3311 - 3314, XP002452928, DOI: 10.1021/ol061233j
WILFRIED, H. ET AL.: "Synthesis of non glycosidic nucleobase-sugar mimetics", COMPTES RENDUS CHIMIE, vol. 13, no. 10, 8 February 2010 (2010-02-08), pages 1284 - 1300, XP027298825
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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