Title:
PREPARATION METHOD FOR IOVERSOL HYDROLYSATE
Document Type and Number:
WIPO Patent Application WO/2023/104063
Kind Code:
A1
Abstract:
A preparation method for ioversol hydrolysate, comprising: with an industrial iodide as a raw material, subjecting the industrial iodide and acetoxyacetyl chloride to an acetoxyacetylation reaction, hydrolyzing same, and regulating the acidity to obtain the ioversol hydrolysate. According to the method, crystallization is performed in an aqueous solution, thereby achieving safety and environmental friendliness; and the obtained target product has a yield of 90% or above and a purity of 99.5% or above, and is suitable for the use as a raw material for the industrial production of ioversol.
Inventors:
RAO JINGWEI (CN)
SHEN YANYANG (CN)
YUE YONGLI (CN)
GU JIANJUN (CN)
LU FEI (CN)
LIN LI (CN)
ZHANG JIAN (CN)
SHEN YANYANG (CN)
YUE YONGLI (CN)
GU JIANJUN (CN)
LU FEI (CN)
LIN LI (CN)
ZHANG JIAN (CN)
Application Number:
PCT/CN2022/137106
Publication Date:
June 15, 2023
Filing Date:
December 07, 2022
Export Citation:
Assignee:
ANQING ROUNDCARE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C231/12; C07C237/46; C07C231/14
Domestic Patent References:
| WO2022002953A1 | 2022-01-06 | |||
| WO1993016981A1 | 1993-09-02 |
Foreign References:
| CN114409566A | 2022-04-29 | |||
| CN109134289A | 2019-01-04 |
Other References:
ZOU PEI, LIU YA-LING, LUO SHI-NENG, XIE MIN-HAO, SHEN YONG, -JIA: "Synthesis of N,N’-Bis（2,3-dihydroxypropyl）-5-[N-（2-hydroxyethyl）-hydroxy-acetamido]-2,4,6-triiodoisophthalamide", CHINESE JOURNAL OF ORGANIC CHEMISTRY, SCIENCE PRESS, BEIJING., CN, vol. 25, no. 10, 1 January 2005 (2005-01-01), CN , pages 1244 - 1247, XP093072603, ISSN: 0253-2786
Attorney, Agent or Firm:
JIANGSU SUNDY LAW FIRM (CN)
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