Title:
PREPARATION METHOD FOR KRAS G12C INHIBITOR AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/226902
Kind Code:
A1
Abstract:
The present invention relates to a preparation method for a KRAS G12C inhibitor and an intermediate thereof. The method has a simple and efficient process route, low cost, low pollution and high safety and does not need column chromatography purification operation, the HPLC purity of a prepared target product is higher than 99.0%, and the ee value of the product is higher than 99.0%, thus the method being suitable for industrial application.
Inventors:
LV BINHUA (CN)
FENG WEIDONG (CN)
LIAN CHANGMING (CN)
WANG RUNQING (CN)
CHENG JIAWEI (CN)
YE WEI (CN)
FENG WEIDONG (CN)
LIAN CHANGMING (CN)
WANG RUNQING (CN)
CHENG JIAWEI (CN)
YE WEI (CN)
Application Number:
PCT/CN2023/095362
Publication Date:
November 30, 2023
Filing Date:
May 19, 2023
Export Citation:
Assignee:
SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
International Classes:
C07D471/04; C07D211/78
Domestic Patent References:
| WO2021078312A1 | 2021-04-29 | |||
| WO2022066646A1 | 2022-03-31 | |||
| WO2021106231A1 | 2021-06-03 | |||
| WO2014166386A1 | 2014-10-16 | |||
| WO2022148422A1 | 2022-07-14 |
Foreign References:
| US20190144444A1 | 2019-05-16 | |||
| US20180072723A1 | 2018-03-15 | |||
| CN110734393A | 2020-01-31 | |||
| CN111989321A | 2020-11-24 |
Other References:
SCALONE MICHELANGELO, WALDMEIER PIUS: "Efficient Enantioselective Synthesis of the NMDA 2B Receptor Antagonist Ro 67-8867", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 7, no. 3, 1 May 2003 (2003-05-01), US , pages 418 - 425, XP093111797, ISSN: 1083-6160, DOI: 10.1021/op034006v
LIAO RONG, ZHOU QING-HAN: "Study on synthesis of 2-(1-(tert-butoxycarbonyl) piperidin-3-yl) acetic acid", XINAN MINZU DAXUE XUEBAO (ZIRAN KEXUE BAN) - SOUTHWEST UNIVERSITYFOR NATIONALITIES. JOURNAL (NATURAL SCIENCE EDITION), XINAN MINZU DAXUE, CHENGDU, CN, vol. 38, no. 4, 25 July 2012 (2012-07-25), CN , pages 587 - 591, XP093111798, ISSN: 1003-2843, DOI: 10.3969/j.issn.1003-2483.2012.04.19
LIAO RONG, ZHOU QING-HAN: "Study on synthesis of 2-(1-(tert-butoxycarbonyl) piperidin-3-yl) acetic acid", XINAN MINZU DAXUE XUEBAO (ZIRAN KEXUE BAN) - SOUTHWEST UNIVERSITYFOR NATIONALITIES. JOURNAL (NATURAL SCIENCE EDITION), XINAN MINZU DAXUE, CHENGDU, CN, vol. 38, no. 4, 25 July 2012 (2012-07-25), CN , pages 587 - 591, XP093111798, ISSN: 1003-2843, DOI: 10.3969/j.issn.1003-2483.2012.04.19
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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