Title:
PREPARATION METHOD FOR MODIFIED TOXIN POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2022/179556
Kind Code:
A1
Abstract:
Provided is a preparation method for a modified toxin polypeptide. The preparation method comprises: step 1): expressing a modified toxin polypeptide precursor; step 2): enriching the toxin polypeptide precursor; and step 3): activating the toxin polypeptide precursor to obtain a modified toxin polypeptide.
Inventors:
ZHANG YAN (CN)
Application Number:
PCT/CN2022/077637
Publication Date:
September 01, 2022
Filing Date:
February 24, 2022
Export Citation:
Assignee:
CHONGQING CLARUVIS PHARMACEUTICAL CO LTD (CN)
International Classes:
C12N15/70
Domestic Patent References:
| WO2019118974A2 | 2019-06-20 |
Foreign References:
| CN107438670A | 2017-12-05 | |||
| CN110072880A | 2019-07-30 | |||
| CN107548402A | 2018-01-05 | |||
| US20100041098A1 | 2010-02-18 | |||
| CN202110217756A | 2021-02-26 | |||
| CN201910673683A | 2019-07-24 |
Other References:
EISELE ET AL., TOXICON, vol. 57, no. 4, 2011, pages 555 - 65
DU JUAN ET AL.: "Targeting Killing Effect of IL-13 Diphtheria Toxin Fusion Protein and DT -hIL13-13E13K", JOURNAL OF MEDICAL RESEARCH, vol. 010, no. 037, 2008, pages 31 - 36
HU ZHIMING ET AL.: "Purification and Renaturation of Recombinant Human Interleukin 2-Pseudomonas Exotoxin (IL2-PE664GlU) Fusion Protein", JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY, 2002, pages 1000 - 2588
DU JUAN ET AL.: "Targeting Killing Effect of IL-13 Diphtheria Toxin Fusion Protein and DT -hIL13-13E13K", JOURNAL OF MEDICAL RESEARCH, vol. 010, no. 037, 2008, pages 31 - 36
HU ZHIMING ET AL.: "Purification and Renaturation of Recombinant Human Interleukin 2-Pseudomonas Exotoxin (IL2-PE664GlU) Fusion Protein", JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY, 2002, pages 1000 - 2588
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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