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Patent Searching and Data


Title:
PREPARATION METHOD FOR NICOTINE AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/228535
Kind Code:
A1
Abstract:
Disclosed in the present invention is a preparation method for nicotine and an intermediate thereof, and particularly disclosed is a preparation method for 4-amino-1-pyridin-3-yl-butan-1-one, the method comprising the following steps: subjecting a nicotinate as represented by formula (I) and N-vinylpyrrolidone to a substitution reaction in a solvent under the action of an alkali; adding an acid to carry out a decarboxylation reaction; and then adjusting the pH to 6 to 8 using an alkali, so as to obtain 4-amino-1-pyridin-3-yl-butan-1-one. According to the method of the present invention, the reaction materials are cheap and easy to obtain, the operation process is simple, and the method is suitable for large-scale industrial production.

Inventors:
SHEN LITAO (CN)
LIU YAOXIU (CN)
FENG PIMING (CN)
TU ZHIBO (CN)
Application Number:
PCT/CN2022/090051
Publication Date:
November 03, 2022
Filing Date:
April 28, 2022
Export Citation:
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Assignee:
WUHAN ZY PHARMACEUTICALS CO LTD (CN)
WUHAN QR PHARMACEUTICALS CO LTD (CN)
HUANGGANG ZY BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D213/50; C07D401/04
Foreign References:
CN114644614A2022-06-21
CN107406411A2017-11-28
CN102633773A2012-08-15
CN112409327A2021-02-26
CN111527077A2020-08-11
CN111511726A2020-08-07
Other References:
SVANTE BRANDANGE , BENITO RODRIQUEZ: "Ring-chain Tautomerism of Myosmine", ACTA CHEMICA SCANDINAVICA B, vol. 37, no. 7, 1 January 1983 (1983-01-01), pages 643 - 644, XP055981525, ISSN: 0904-213X, DOI: 10.3891/acta.chem.scand.37b-0643
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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