Title:
PREPARATION METHOD FOR NICOTINE AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/228535
Kind Code:
A1
Abstract:
Disclosed in the present invention is a preparation method for nicotine and an intermediate thereof, and particularly disclosed is a preparation method for 4-amino-1-pyridin-3-yl-butan-1-one, the method comprising the following steps: subjecting a nicotinate as represented by formula (I) and N-vinylpyrrolidone to a substitution reaction in a solvent under the action of an alkali; adding an acid to carry out a decarboxylation reaction; and then adjusting the pH to 6 to 8 using an alkali, so as to obtain 4-amino-1-pyridin-3-yl-butan-1-one. According to the method of the present invention, the reaction materials are cheap and easy to obtain, the operation process is simple, and the method is suitable for large-scale industrial production.
Inventors:
SHEN LITAO (CN)
LIU YAOXIU (CN)
FENG PIMING (CN)
TU ZHIBO (CN)
LIU YAOXIU (CN)
FENG PIMING (CN)
TU ZHIBO (CN)
Application Number:
PCT/CN2022/090051
Publication Date:
November 03, 2022
Filing Date:
April 28, 2022
Export Citation:
Assignee:
WUHAN ZY PHARMACEUTICALS CO LTD (CN)
WUHAN QR PHARMACEUTICALS CO LTD (CN)
HUANGGANG ZY BIOTECHNOLOGY CO LTD (CN)
WUHAN QR PHARMACEUTICALS CO LTD (CN)
HUANGGANG ZY BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D213/50; C07D401/04
Foreign References:
| CN114644614A | 2022-06-21 | |||
| CN107406411A | 2017-11-28 | |||
| CN102633773A | 2012-08-15 | |||
| CN112409327A | 2021-02-26 | |||
| CN111527077A | 2020-08-11 | |||
| CN111511726A | 2020-08-07 |
Other References:
SVANTE BRANDANGE , BENITO RODRIQUEZ: "Ring-chain Tautomerism of Myosmine", ACTA CHEMICA SCANDINAVICA B, vol. 37, no. 7, 1 January 1983 (1983-01-01), pages 643 - 644, XP055981525, ISSN: 0904-213X, DOI: 10.3891/acta.chem.scand.37b-0643
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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