Title:
PREPARATION METHOD FOR NICOTINE
Document Type and Number:
WIPO Patent Application WO/2024/000877
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method for nicotine. The preparation method for nicotine comprises the following steps: photocatalytically synthesizing an intermediate N-tert-butyloxycarbonyl-nornicotine with 3-bromopyridine and N-tert-butyloxycarbonyl-proline as raw materials; then carrying out a reaction on the N-tert-butyloxycarbonyl-nornicotine and trifluoroacetic acid to remove the tert-butyloxycarbonyl group, so as to synthesize nornicotine; and finally, subjecting the nornicotine to a methylation reaction to synthesize nicotine. The preparation method for nicotine in the present invention has a short synthesis route, simple operations, high yield and low cost, and is suitable for industrial mass production.
Inventors:
WANG CHENG (CN)
LI JIANG (CN)
HE ZE (CN)
LI JIANG (CN)
HE ZE (CN)
Application Number:
PCT/CN2022/122057
Publication Date:
January 04, 2024
Filing Date:
September 28, 2022
Export Citation:
Assignee:
HUBEI HENO BIOLOGICAL ENG CO LTO (CN)
International Classes:
C07D401/04
Foreign References:
| CN112745294A | 2021-05-04 |
Other References:
ABDIAJ IRINI; ALCAZAR JESUS: "Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)C(sp3) cross-coupling", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 25, no. 23, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 6190 - 6196, XP085251496, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2016.12.041
Attorney, Agent or Firm:
HUBEI GROWTOP LAW FIRM (CN)
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