Title:
PREPARATION METHOD FOR PYRROLE-2-SULFONAMIDE COMPOUND AND APPLICATION THEREOF IN PREPARING ANTI-TUMOR DRUG
Document Type and Number:
WIPO Patent Application WO/2022/205586
Kind Code:
A1
Abstract:
A preparation method for a pyrrole-2-sulfonamide compound or a pharmaceutically acceptable salt thereof, and an application thereof in preparing an anti-tumor drug, the pyrrole-2-sulfonamide compound having a structure represented by formula I. The compound N-(5-chloro-2-methylphenyl)-5-(5-(4-fluorophenyl)-1, 3, 4-oxadiazole-2-yl)-1H-pyrrole-2-sulfonamide represented by formula I has anti-tumor activity, has a good inhibitory effect on a plurality of primary and transformed tumor cells, and can be used to prepare an anti-tumor drug.
Inventors:
TIAN SHENG (CN)
LI HUANQIU (CN)
WANG WEIPENG (CN)
LIN ZHIQIAN (CN)
WU SHUYE (CN)
LI HUANQIU (CN)
WANG WEIPENG (CN)
LIN ZHIQIAN (CN)
WU SHUYE (CN)
Application Number:
PCT/CN2021/095190
Publication Date:
October 06, 2022
Filing Date:
May 21, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K31/4245; A61P35/00; C07D413/04
Domestic Patent References:
| WO2002088097A1 | 2002-11-07 | |||
| WO2006116355A1 | 2006-11-02 | |||
| WO2020170203A1 | 2020-08-27 |
Foreign References:
| CN87103542A | 1988-02-03 | |||
| CN1549714A | 2004-11-24 | |||
| CN101910165A | 2010-12-08 | |||
| CN1735611A | 2006-02-15 |
Other References:
K. JONES M. SWAPNAJA, SATYANARAYANA YENNAM, MURTHY CHAVALI, Y. POORNACHANDRA, C. GANESH KUMAR, KRUBAKARAN MUTHUSAMY, VENKATESH BAB: "Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 117, no. 126, 6 April 2016 (2016-04-06), AMSTERDAM, NL , pages 85 - 98, XP055489809, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2016.03.042
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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