Title:
PREPARATION METHOD FOR SUBSTITUTED PHENYLACETIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/228149
Kind Code:
A1
Abstract:
The present invention belongs to the field of pharmaceutical synthesis, and relates to a preparation method for a substituted phenylacetic acid derivative, in particular to a method for preparing 2-[4-(2-oxopentylmethyl)phenylpropionic acid]. Said preparation method comprises a Friedel-Crafts reaction, and a cyclization reaction and a coupling reaction of which the sequence can be exchangeable, and a reduction reaction. The preparation method is neither taught in the prior art, nor can any technical motivation be obtained from the prior art. The preparation method is suitable for the production in commercial scale, and provides another technical solution for the industrial production of loxoprofen sodium.
More Like This:
Inventors:
GAO ZHAOBO (CN)
ZHEN HUI (CN)
LIU SHENGMIN (CN)
LI JIEPING (CN)
WANG CHANGFA (CN)
ZHENG JUNCHENG (CN)
GUO BIBAO (CN)
SONG LIANG (CN)
LIU AQING (CN)
HU KAI (CN)
MEI YIJIANG (CN)
ZHEN HUI (CN)
LIU SHENGMIN (CN)
LI JIEPING (CN)
WANG CHANGFA (CN)
ZHENG JUNCHENG (CN)
GUO BIBAO (CN)
SONG LIANG (CN)
LIU AQING (CN)
HU KAI (CN)
MEI YIJIANG (CN)
Application Number:
PCT/CN2018/087969
Publication Date:
December 20, 2018
Filing Date:
May 23, 2018
Export Citation:
Assignee:
ZHEJIANG JIUZHOU PHARM CO LTD (CN)
International Classes:
C07C51/347; C07C51/41; C07C59/86; C07C67/30; C07C69/738
Foreign References:
US4407823A | 1983-10-04 | |||
CN106316837A | 2017-01-11 | |||
DE2702911A1 | 1978-07-27 |
Download PDF:
Previous Patent: WIRELESS COMMUNICATION NETWORK PLANNING METHOD, DEVICE AND SYSTEM
Next Patent: DOWNLINK TRANSMISSION IN A RAN INACTIVE MODE
Next Patent: DOWNLINK TRANSMISSION IN A RAN INACTIVE MODE