PREPARATION METHOD FOR SUBSTITUTED PHENYLACETIC ACID DERIVATIVE

WIPO Patent Application WO/2018/228149

A1

The present invention belongs to the field of pharmaceutical synthesis, and relates to a preparation method for a substituted phenylacetic acid derivative, in particular to a method for preparing 2-[4-(2-oxopentylmethyl)phenylpropionic acid]. Said preparation method comprises a Friedel-Crafts reaction, and a cyclization reaction and a coupling reaction of which the sequence can be exchangeable, and a reduction reaction. The preparation method is neither taught in the prior art, nor can any technical motivation be obtained from the prior art. The preparation method is suitable for the production in commercial scale, and provides another technical solution for the industrial production of loxoprofen sodium.

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GAO ZHAOBO (CN)
ZHEN HUI (CN)
LIU SHENGMIN (CN)
LI JIEPING (CN)
WANG CHANGFA (CN)
ZHENG JUNCHENG (CN)
GUO BIBAO (CN)
SONG LIANG (CN)
LIU AQING (CN)
HU KAI (CN)
MEI YIJIANG (CN)

PCT/CN2018/087969

December 20, 2018

May 23, 2018

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ZHEJIANG JIUZHOU PHARM CO LTD (CN)

C07C51/347; C07C51/41; C07C59/86; C07C67/30; C07C69/738

US4407823A	1983-10-04
CN106316837A	2017-01-11
DE2702911A1	1978-07-27

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