Title:
PREPARATION METHOD FOR SULFINPYRAZONE
Document Type and Number:
WIPO Patent Application WO/2023/060856
Kind Code:
A1
Abstract:
Disclosed in the present invention is a preparation method for sulfinpyrazone. The sulfinpyrazone is prepared by means of the steps of: using thiophenol as an initiator, electrocatalytically coupling same with dichloroethane to obtain 2-chloroethyl phenyl sulfide, then subjecting same to a substitution reaction with 1,2-diphenyl-3,5-pyrazolidinedione to obtain sulfinpyrazone. The method is a two-step reaction, and has a total yield of 48%. Compared with the prior art, the method has the characteristics of a high yield, short steps, few three wastes, good chemical selectivity, no need for a strong base and oxidant, safe and convenient operation and easy realization of industrial production.
Inventors:
FENG YU (CN)
QIAN WEI (CN)
XU YANPING (CN)
GAO LIYAN (CN)
ZHONG WEIHUI (CN)
LING FEI (CN)
LIU TAO (CN)
QIAN WEI (CN)
XU YANPING (CN)
GAO LIYAN (CN)
ZHONG WEIHUI (CN)
LING FEI (CN)
LIU TAO (CN)
Application Number:
PCT/CN2022/086078
Publication Date:
April 20, 2023
Filing Date:
April 11, 2022
Export Citation:
Assignee:
CHENGDA PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D231/36; C25B3/09; C25B3/23
Foreign References:
| CN113929625A | 2022-01-14 | |||
| US4288602A | 1981-09-08 | |||
| CH532582A | 1973-01-15 |
Other References:
LI JIPENG, HE ZI YI, LIANG DONG YAN: "IMPROVED SYNTHESIS OF SULFINPYRAZONE", CHINESE JOURNAL OF PHARMACEUTICALS, SHANGHAI YIYAO GONGYE YANJIUYUAN,SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, CN, vol. 30, no. 3, 31 December 1999 (1999-12-31), CN , XP093057567, ISSN: 1001-8255, DOI: 10.16522/j.cnki.cjph.1999.03.002
YU YAXIN, MO YAN, HAIYING GAO: "Research on Synthesis of Sulfinpyrazone", SHANDONG CHEMICAL INDUSTRY, vol. 45, no. 3, 31 December 2016 (2016-12-31), pages 8 - 9, XP093057569, ISSN: 1008-021x, DOI: 10.19319/j.cnki.issn.1008-021x.2016.03.006
YU YAXIN, MO YAN, HAIYING GAO: "Research on Synthesis of Sulfinpyrazone", SHANDONG CHEMICAL INDUSTRY, vol. 45, no. 3, 31 December 2016 (2016-12-31), pages 8 - 9, XP093057569, ISSN: 1008-021x, DOI: 10.19319/j.cnki.issn.1008-021x.2016.03.006
Attorney, Agent or Firm:
JIAXING QIFAN PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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