Title:
PREPARATION OF NOVEL ISOPHORONE DERIVATIVES AND USE THEREOF IN FIELDS OF ORGANELLE LABELING AND VISCOSITY DETECTION
Document Type and Number:
WIPO Patent Application WO/2023/087503
Kind Code:
A1
Abstract:
Compound (3,5,5-trimethylcyclohex-2-enylidene)malononitrile reacts with different building blocks containing aldehyde groups to obtain four isophorone derivatives. The derivatives can mark mitochondria, lysosomes, endoplasmic reticula or lipid droplets, are sensitive to viscosity, and are remarkably enhanced in fluorescence in a viscous environment. The derivatives can perform organelle targeting capability adjustment, so that it is possible to design fluorescent markers having different organelle targeting capabilities by using a single basic framework structure.
Inventors:
GE JIANFENG (CN)
YU QING (CN)
NI JINGYANG (CN)
SUN RU (CN)
YU QING (CN)
NI JINGYANG (CN)
SUN RU (CN)
Application Number:
PCT/CN2021/143128
Publication Date:
May 25, 2023
Filing Date:
December 30, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07C253/30; C07D231/56; C07D211/46; C09K11/06; G01N21/64
Foreign References:
| CN104860879A | 2015-08-26 | |||
| CN109836394A | 2019-06-04 |
Other References:
CHEN DUGANG, NIE GANG, DANG YECHENG, LIANG WENJIE, LI WANQING, ZHONG CHENG: "Rational design of near-infrared fluorophores with a phenolic D–A type structure and construction of a fluorescent probe for cysteine imaging", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 45, no. 39, 11 October 2021 (2021-10-11), GB , pages 18528 - 18537, XP093067303, ISSN: 1144-0546, DOI: 10.1039/D1NJ02459K
ERANDE, Y. ET AL.: "Spectroscopic, DFT and Z-scan supported investigation of dicyanoisophorone based push-pull NLOphoric styryl dyes", OPTICAL MATERIALS, vol. 66, 8 March 2017 (2017-03-08), pages 494 - 511, XP029966381, DOI: 10.1016/j.optmat.2017.03.005
ZHANG WANG, LIU JIA, YU YUEWEN, HAN QIAORONG, CHENG TIAN, SHEN JIAN, WANG BINGXIANG, JIANG YULIANG: "A novel near-infrared fluorescent probe for highly selective detection of cysteine and its application in living cells", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 185, 1 August 2018 (2018-08-01), NL , pages 477 - 482, XP093067307, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2018.04.001
ERANDE, Y. ET AL.: "Spectroscopic, DFT and Z-scan supported investigation of dicyanoisophorone based push-pull NLOphoric styryl dyes", OPTICAL MATERIALS, vol. 66, 8 March 2017 (2017-03-08), pages 494 - 511, XP029966381, DOI: 10.1016/j.optmat.2017.03.005
ZHANG WANG, LIU JIA, YU YUEWEN, HAN QIAORONG, CHENG TIAN, SHEN JIAN, WANG BINGXIANG, JIANG YULIANG: "A novel near-infrared fluorescent probe for highly selective detection of cysteine and its application in living cells", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 185, 1 August 2018 (2018-08-01), NL , pages 477 - 482, XP093067307, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2018.04.001
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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