Title:
PREPARATION, RAW MATERIALS, PRODUCT, AND APPLICATION OF PHOTOCOUPLED SYNERGISTIC CROSSLINKED HYDROGEL MATERIAL
Document Type and Number:
WIPO Patent Application WO/2019/095600
Kind Code:
A1
Abstract:
Provided are preparation, raw materials, a product, and an application of a photocoupled synergistic crosslinked hydrogel material. The material is prepared by: dissolving a component A, a polymer derivative modified by an o-nitrobenzyl light trigger in a biocompatible medium to obtain a solution A, and dissolving a component B, an amino-containing polymer derivative or a double bond-containing polymer derivative or a fluorenyl-containing polymer derivative in the biocompatible medium to obtain a solution B; uniformly mixing the solution A, or adding the solution B thereto, to obtain a hydrogel precursor solution; irradiating the hydrogel precursor solution with a light source, such that the o-nitrobenzyl group in the component A simultaneously generates an aldehyde group/ketone group or a nitroso group under photoexcitation for double crosslinking, achieving a synergistic crosslinking effect. Further provided are a kit for the preparation of the hydrogel, as well as applications of the hydrogel material for use in tissue engineering, regenerative medicine, and 3D printing and as a carrier for cells, proteins, or drugs.
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Inventors:
ZHU LINYONG (CN)
HUA YUJIE (CN)
LIN QIUNING (CN)
ZHANG YIQING (CN)
BAO CHUNYAN (CN)
ZHONG XUEPENG (CN)
HUA YUJIE (CN)
LIN QIUNING (CN)
ZHANG YIQING (CN)
BAO CHUNYAN (CN)
ZHONG XUEPENG (CN)
Application Number:
PCT/CN2018/080174
Publication Date:
May 23, 2019
Filing Date:
March 23, 2018
Export Citation:
Assignee:
UNIV EAST CHINA SCIENCE & TECH (CN)
International Classes:
C07D291/08; C08B11/12; C08B37/02; C08B37/04; C08B37/08; C08B37/10; C08G65/334; C08G69/48; C08H1/00
Foreign References:
| CN106822183A | 2017-06-13 | |||
| CN105131315A | 2015-12-09 | |||
| US20160108172A1 | 2016-04-21 | |||
| US6020480A | 2000-02-01 |
Other References:
BAO, CHUNYAN: "Long conjugated 2-nitrobenzyl derivative caged anticancer prodrugs with visible light regulated release: preparation and functionalizations", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 10, no. 27, 31 December 2012 (2012-12-31), pages 5238 - 5244, XP055609345
LIN QIUNING ET AL.: "Phototriggers: Work mechanisms and applications", IMAGING SCIENCE AND PHOTOCHEMISTRY, vol. 32, no. 1, 31 January 2014 (2014-01-31), pages 4 - 5, XP055609347
LIN QIUNING ET AL.: "Phototriggers: Work mechanisms and applications", IMAGING SCIENCE AND PHOTOCHEMISTRY, vol. 32, no. 1, 31 January 2014 (2014-01-31), pages 4 - 5, XP055609347
Attorney, Agent or Firm:
SHANGHAI KESHENG INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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